Radiation Therapy for Breast Cancer
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment External Beam Radiation Therapy (EBRT) for breast cancer?
External Beam Radiation Therapy (EBRT) has been shown to be effective in treating various cancers, such as prostate cancer, by improving survival rates and reducing cancer recurrence. While this data is specific to prostate cancer, it suggests that EBRT can be a powerful tool in managing cancer, potentially including breast cancer.12345
Is external beam radiation therapy (EBRT) generally safe for humans?
How does external beam radiation therapy (EBRT) for breast cancer differ from other treatments?
External beam radiation therapy (EBRT) is unique because it is a non-invasive treatment that uses high-energy rays to target and destroy cancer cells in the breast, often as part of breast-conserving therapy. Unlike some other treatments, EBRT can be extended to target additional areas like the supraclavicular fossa and internal mammary chain, providing comprehensive coverage for high-risk patients.1891011
What is the purpose of this trial?
Single-arm, phase 2 study evaluating hypofractionated irradiation of breast and regional nodes in women with breast cancer. Patients will be grouped in 3 surgery-related treatment groups: 1) An intact breast following lumpectomy; 2) plans for loco regional external beam radiotherapy (EBRT) following mastectomy (with or without plans for reconstruction); and 3) plans for locoregional EBRT following mastectomy with reconstruction.Patients will be assessed for lymphedema, arm function, breast or chestwall pain, other EBRT-related adverse events, and, for patients who had a lumpectomy or mastectomy with reconstruction, cosmetic outcome.
Research Team
Douglas W Arthur, M.D.
Principal Investigator
Massey Cancer Center
Eligibility Criteria
This trial is for women with breast cancer who've had surgery, have healed incisions without infection, and tested ER, PR, HER2 on the tumor. They must understand English consent forms, not be pregnant or breastfeeding, use birth control during the study, and meet specific criteria related to their cancer stage and treatment history.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo hypofractionated regional nodal irradiation (RNI) five days a week over 3-4 weeks
Follow-up
Participants are monitored for lymphedema, arm function, pain, and other adverse events every 6 months
Treatment Details
Interventions
- External Beam Radiation Therapy
External Beam Radiation Therapy is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Various types of cancer, including but not limited to breast, lung, prostate, and brain cancers
- Various types of cancer, including but not limited to breast, lung, prostate, and brain cancers
- Various types of cancer, including but not limited to breast, lung, prostate, and brain cancers
- Various types of cancer, including but not limited to breast, lung, prostate, and brain cancers
- Various types of cancer, including but not limited to breast, lung, prostate, and brain cancers
- Various types of cancer, including but not limited to breast, lung, prostate, and brain cancers
Find a Clinic Near You
Who Is Running the Clinical Trial?
Virginia Commonwealth University
Lead Sponsor