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Tyrosine Kinase Inhibitor
VEGF-TKI for Kidney Cancer
N/A
Waitlist Available
Led By Sumanta Pal
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2.5 years
Awards & highlights
Study Summary
This trial looks at whether probiotic yogurt can help reduce diarrhea in people with metastatic kidney cancer who are taking VEGF-TKI therapy. Blood and stool samples will be studied to see if probiotic yogurt is a helpful treatment.
Eligible Conditions
- Kidney Cancer
- Renal Cell Carcinoma
- Diarrhea
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 2.5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 2.5 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Number of Participants With Diarrhea
Number of Participants With Overall Response
Secondary outcome measures
Clinical Benefit Rate
Progression-free Survival (PFS)
Other outcome measures
Gene Expression Profiling
Feasibility of bacteriomic profiling measured by viable bacteriomic profile results
Feasibility of stool collection measured by compliance with specimen submission
+2 moreTrial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Arm I (probiotic yogurt supplement)Experimental Treatment3 Interventions
Patients receive probiotic supplement Activia yogurt QD during weeks 2-13 of VEGF-TKI treatment.
Group II: Arm II (no intervention)Active Control2 Interventions
Patients avoid any intake of yogurt or yogurt-containing foods and refrain from taking/consuming other probiotic supplements for 3 months.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Micronutrient-Fortified Probiotic Yogurt
2016
N/A
~30
VEGF-TKI
2016
N/A
~30
Find a Location
Who is running the clinical trial?
City of Hope Medical CenterLead Sponsor
565 Previous Clinical Trials
1,921,439 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,662 Previous Clinical Trials
40,925,860 Total Patients Enrolled
Sumanta PalPrincipal InvestigatorCity of Hope Medical Center
2 Previous Clinical Trials
39 Total Patients Enrolled
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is recruitment currently available for this research project?
"This trial is no longer recruiting subjects, having been initially posted on November 11th 2016 and most recently edited on June 7th 2022. However, 2658 other medical studies are presently welcoming participants."
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