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Beta Blocker

Catecholamine Blockade for Burns

N/A

Waitlist Available

Led By Marc G Jeschke, MD PhD

Research Sponsored by Sunnybrook Health Sciences Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up daily until discharge (1-4 months post admission depending on severity)

Awards & highlights

Study Summary

This trial is testing whether or not blocking stress hormones will help improve outcomes for people with severe burns.

Who is the study for?

This trial is for adults aged 18 to 90 who have suffered burns covering more than 25% of their body. It's not suitable for those who are critically ill at the point of admission or if a decision has been made not to treat them because of the severity of their burn injuries.Check my eligibility

What is being tested?

The study is testing whether propranolol, a drug that blocks stress signals in the body, can improve recovery after severe burns by reducing inflammation and other harmful responses. Participants will be randomly given either propranolol or a placebo.See study design

What are the potential side effects?

Propranolol may cause side effects such as slower heart rate, low blood pressure, fatigue, dizziness, and may worsen symptoms in people with asthma or certain heart conditions.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ daily until discharge (1-4 months post admission depending on severity)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~daily until discharge (1-4 months post admission depending on severity)

This trial's timeline: 3 weeks for screening, Varies for treatment, and daily until discharge (1-4 months post admission depending on severity) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Perform oral glucose tolerance test

Secondary outcome measures

Measure concentrations of serum cytokines

Measure the levels of activated signaling proteins using protein blotting

Record the episodes of Pneumonia

+1 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Beta blockadeExperimental Treatment1 Intervention

Group II: ControlPlacebo Group1 Intervention

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

propranolol

2016

Completed Phase 4

~630

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor

656 Previous Clinical Trials

1,550,597 Total Patients Enrolled

5 Trials studying Burns

406 Patients Enrolled for Burns

Marc G Jeschke, MD PhDPrincipal InvestigatorSunnybrook Health Sciences Centre

4 Previous Clinical Trials

364 Total Patients Enrolled

4 Trials studying Burns

364 Patients Enrolled for Burns

Media Library

Propranolol (Beta Blocker) Clinical Trial Eligibility Overview. Trial Name: NCT01299753 — N/A

Burns Research Study Groups: Beta blockade, Control

Burns Clinical Trial 2023: Propranolol Highlights & Side Effects. Trial Name: NCT01299753 — N/A

Propranolol (Beta Blocker) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01299753 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what extent is the capacity of this clinical trial being maximized?

"This clinical trial is currently not accepting any more participants. It was initially posted on February 1st 2011 and last updated on March 24th 2022. However, there are 74 active studies for burns and 41 trials for propranolol recruting patients presently."

Answered by AI

Are there any remaining openings for participants in this research?

"Unfortunately, this medical trial has already concluded its recruitment phase. The original posting date was February 1st 2011 and the last update being March 24th 2022. However, there are 74 clinical trials concerning burns that require volunteers as well as 41 studies involving propranolol with open enrollment periods still available."

Answered by AI

Is this research study permitting those aged 65 and over to participate?

"This clinical trial includes individuals aged 18 to 90. There are 27 trials for those younger than eighteen and 89 studies available for seniors above 65 years of age."

Answered by AI

What medical indications is propranolol most frequently employed to address?

"Propranolol can be used to provide relief from cardiovascular mortality, angina pectoris, and myocardial infarction."

Answered by AI

Do I fulfill the criteria to join this medical experiment?

"Eligibility requirements for this clinical trial include having a burn injury and being between 18-90 years old. There are 80 individuals that need to be recruited in total."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Catecholamine Blockade Post-burn

Dr. Marc Jeschke 2011. "Catecholamine Blockade Post-burn". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01299753.