Attention-restorative therapy (ART)-based virtual reality (VR) for Cognitive Decline

Phase-Based Estimates
1
Effectiveness
1
Safety
University of Michigan Rogel Cancer Center, Ann Arbor, MI
Cognitive Decline+3 More
Attention-restorative therapy (ART)-based virtual reality (VR) - Other
Eligibility
18+
Female
Eligible conditions
Cognitive Decline

Study Summary

This study is evaluating whether a virtual reality headset can be used to provide nature-based attention-restorative therapy for cancer survivors.

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Eligible Conditions

  • Cognitive Decline
  • Cognitive Dysfunction
  • Breast Cancer
  • Breast Cancer Survivorship
  • Cancer-related Cognitive Impairment
  • Breast Neoplasms

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Attention-restorative therapy (ART)-based virtual reality (VR) will improve 1 primary outcome and 3 secondary outcomes in patients with Cognitive Decline. Measurement will happen over the course of 6 weeks.

6 weeks
Adherence rate (acceptability)
Attrition rate (feasibility)
Participant experience assessed using Thematic Analysis
Week 6
Impact of intervention, measured by Functional Assessment of Cancer Therapy-Cognitive Function (Fact-Cog) questionnaire

Trial Safety

Trial Design

2 Treatment Groups

No Control Group
ART VR 4 times/week

This trial requires 30 total participants across 2 different treatment groups

This trial involves 2 different treatments. Attention-restorative Therapy (ART)-based Virtual Reality (VR) is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

ART VR 4 times/week
Other
ART VR practice for 30 minutes, at home, 4 times per week
ART VR 3 times/week
Other
ART VR practice for 30 minutes, at home, 3 times per week

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: at baseline, week 4 and week 6
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly at baseline, week 4 and week 6 for reporting.

Closest Location

University of Michigan Rogel Cancer Center - Ann Arbor, MI

Eligibility Criteria

This trial is for female patients aged 18 and older. There are 9 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Female
Age ≥18
Stage I-III breast cancer
Reports a negative change in cognitive function since their cancer diagnosis and rate their cognitive fatigue using a single item questions as a ≥4 on a numeric rating scale of 0-10 for 1 month or more.
Completed primary treatment (chemotherapy, radiation and/or surgery) ≥ 3 months but no more than 10 years prior to registration.
May use concurrent adjuvant endocrine therapy and/or HER2-targeted therapy while on study.
Ability to provide informed written consent.
Ability to read and write English.
Ability to be independent in decision making. Must respond No to "Do you have a guardian or blanket power of attorney for legal transactions?"

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does cognitive decline run in families?

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Results from a recent paper of this study suggest that SLE and CPZ are associated with cognitive impairment, but it remains unclear whether this is familial or due to shared environmental factors.

Unverified Answer

What are the latest developments in attention-restorative therapy (art)-based virtual reality (vr) for therapeutic use?

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Successful application of an art-based VR system for cognitive enhancement showed significant effects on several neuropsychological measures. Art-based interventions seem very promising as a method to influence brain processes involved in attention. Future research applying this sort of technology may reveal additional insights into the mechanisms underlying its effects.

Unverified Answer

Does attention-restorative therapy (art)-based virtual reality (vr) improve quality of life for those with cognitive decline?

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Art-based VR was associated with greater improvement in HRQoL than standard care. Results from a recent paper suggest that art-based VR could be an effective intervention for improving HRQoL in persons with mild, moderate, or severe cognitive impairment.

Unverified Answer

What are the common side effects of attention-restorative therapy (art)-based virtual reality (vr)?

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Art-based vr has shown promise in relieving psychiatric symptoms among persons with dementia. However, this study shows that the side effects experienced during art-based vr were similar to those encountered during other computerized therapies used in patients with dementia. Further research is needed on the optimal dose and length of treatment schedules for art-based vr.

Unverified Answer

What is attention-restorative therapy (art)-based virtual reality (vr)?

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Art-based VR demonstrated increased alerting and orienting responses similarly to a placebo art intervention, but did not improve memory recall. Findings from a recent study should be interpreted cautiously considering the relatively small sample size and the use of a non-standardized learning paradigm.

Unverified Answer

What causes cognitive decline?

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Cognitive decline is not inevitable but is related strongly to age, gender, race, education, and occupation. Elderly people are less likely to have problems with memory, reasoning, and problem solving. Women are more likely than men to show signs of loss of intellectual abilities. People with higher educational status typically show fewer signs of cognitive decline than those who have lower levels of schooling. People with higher occupational rank generally have better cognition than those working in lower positions. The cause of cognitive decline remains unclear.

Unverified Answer

Is attention-restorative therapy (art)-based virtual reality (vr) safe for people?

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Recent findings of this pilot study provide preliminary evidence that ART-based VR can have an immediate positive effect on vigilance and attention. Further research into ART-based VR as an adjunct to other treatments in the management of cognitive dysfunction is now warranted.

Unverified Answer

What does attention-restorative therapy (art)-based virtual reality (vr) usually treat?

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Findings from a recent study demonstrates that art-based VR improves attentional control and reduces attentional bias in healthy subjects. These effects seem to be mediated by a direct effect of art-based VR on attentional processes. Art-based VR may also improve cognitive performance during everyday tasks in older persons with mild-to-moderate dementia. Furthermore, this study provides preliminary evidence that different art-based VR treatments may be effective in different cognitive domains and may have differential effects on attentional bias.

Unverified Answer

What is cognitive decline?

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We found that subjects with early Alzheimer's disease had significantly higher cognitive scores at baseline than non-symptomatic individuals. Cognitive decline was more common among symptomatic patients than among those diagnosed with AD at an earlier age, suggesting that symptomatic Alzheimer's disease progresses faster than expected. Older age at diagnosis predicted rapid cognitive decline, whereas female sex and APOE ε4 status were protective factors. Findings from a recent study suggest that cognitive decline occurs later in Alzheimer's disease and that it may occur before the onset of symptoms.

Unverified Answer

How quickly does cognitive decline spread?

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Results from a recent paper shows that even short intervals of cognitive decline may be associated with decreased quality of life and higher rates of disability and mortality. Results from a recent paper are consistent with previous studies showing that cognitive decline is associated with increased morbidity and mortality.

Unverified Answer

What is the survival rate for cognitive decline?

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The 5-year survival rate for dementia is 14.8%. However, only 9% of patients survive past 10 years. Half of the surviving patients who developed dementia were able to maintain their level of function.

Unverified Answer
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