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typhoid vaccine for Breast Cancer (IMPACT Trial)

Phase < 1
Waitlist Available
Led By Janice Kiecolt-Glaser, PhD
Research Sponsored by Ohio State University Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at baseline prior to vaccine or placebo administration, and then every 90 minutes post-inoculation for 7.5 hours.
Awards & highlights

IMPACT Trial Summary

This trial is studying an inactive typhoid vaccine to see if it can cause an immune response in patients with stage I-IIIA breast cancer. Researchers want to see if patients' fitness levels affect how their bodies handle a challenge to their immune system.

Eligible Conditions
  • Breast Cancer
  • Cognitive Side Effects
  • Depression

IMPACT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at baseline prior to vaccine or placebo administration, and then every 90 minutes post-inoculation for 7.5 hours.
This trial's timeline: 3 weeks for screening, Varies for treatment, and at baseline prior to vaccine or placebo administration, and then every 90 minutes post-inoculation for 7.5 hours. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in level of IL-6
Secondary outcome measures
Change in fatigue
Change in pain

IMPACT Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Arm I (inactive typhoid vaccine, placebo)Experimental Treatment2 Interventions
Patients receive inactive typhoid vaccine IM at visit 1 followed by placebo IM 30 days later at visit 2.
Group II: Arm II (placebo, inactive typhoid vaccine)Placebo Group2 Interventions
Patients receive placebo IM at visit 1 followed by inactive typhoid vaccine IM 30 days later at visit 2.

Find a Location

Who is running the clinical trial?

Ohio State University Comprehensive Cancer CenterLead Sponsor
320 Previous Clinical Trials
289,958 Total Patients Enrolled
22 Trials studying Breast Cancer
2,884 Patients Enrolled for Breast Cancer
Janice Kiecolt-Glaser, PhDPrincipal Investigator - Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Wexner Medical Center
Ohio State University Comprehensive Cancer Center
2 Previous Clinical Trials
256 Total Patients Enrolled
1 Trials studying Breast Cancer
200 Patients Enrolled for Breast Cancer

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Typhoid Vaccine in Testing Response to Immune Stress in Patients With Stage I-IIIA Breast Cancer
Janice Kiecolt-Glaser 2014. "Typhoid Vaccine in Testing Response to Immune Stress in Patients With Stage I-IIIA Breast Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02415387.
~19 spots leftby Apr 2025
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