Advanced MRI for Recurrent Brain Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores new MRI techniques to help doctors distinguish between recurring brain tumors and radiation treatment damage. Standard MRI scans often struggle to differentiate these conditions due to their similar appearance. The trial employs advanced MRI imaging, including DR-CSI and sodium imaging, to enhance diagnostic accuracy. Ideal candidates for this trial are individuals diagnosed with a brain tumor who are scheduled for surgery or specialized radiation treatment (SRS). Participants will undergo these advanced scans before their planned procedures. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could enhance diagnostic accuracy for future patients.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that these advanced MRI techniques are safe for identifying recurrent brain tumors?
Research has shown that advanced MRI techniques, such as DR-CSI and sodium imaging, are generally safe for people. These methods help doctors better understand and treat brain conditions. No reports indicate that these MRI techniques cause harm or serious side effects.
MRI, a common medical tool, uses magnets and radio waves to capture images inside the body. Advanced MRI techniques offer more detailed images without adding risk to patients.
Overall, advanced MRI is well-tolerated, and previous studies have not identified specific safety concerns. It is considered a safe way to gather more information about brain tumors and other brain issues.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores the use of advanced MRI techniques, like DR-CSI and sodium MRI, to improve the management of recurrent brain cancer. Unlike standard MRI, these advanced methods provide more detailed images of the tumor's metabolic and chemical environment, potentially allowing for more precise surgical planning and treatment monitoring. This could lead to better outcomes by targeting the cancer more accurately and adjusting treatments based on clearer insights into tumor behavior over time.
What evidence suggests that advanced MRI techniques are effective for identifying recurrent brain tumors versus radiation necrosis?
Research has shown that advanced MRI techniques, such as diffusion-relaxation correlation spectrum imaging (DR-CSI) and sodium imaging, can distinguish between returning brain tumors and radiation damage. In this trial, participants will undergo these advanced MRI methods, which studies have found to diagnose conditions like glioblastoma more accurately than traditional MRI. These techniques help doctors determine whether a tumor is regrowing or if it's merely a treatment side effect. By clarifying these distinctions, advanced MRI may enhance treatment planning for patients with recurring brain cancer.678910
Who Is on the Research Team?
Jingwen Yao
Principal Investigator
UCLA / Jonsson Comprehensive Cancer Center
Are You a Good Fit for This Trial?
This trial is for adults over 18 with metastatic brain tumors. Participants must be scheduled for surgical resection, tissue biopsy, or laser therapy (LITT), or set to receive stereotactic radiosurgery (SRS).Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Advanced MRI and Tissue Collection
Patients undergo advanced DR-CSI and sodium MRI over 30 minutes prior to SOC surgical resection or biopsy. Patients also undergo clinical MRI and tissue sample collection on study.
Post-SRS Imaging
Patients undergo advanced DR-CSI and sodium MRI over 30 minutes before SRS and at 2 weeks, 3 months, and 6 months post-SRS. Patients also undergo clinical MRI on study.
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Advanced Magnetic Resonance Imaging
Trial Overview
The study tests advanced MRI techniques like DR-CSI and sodium imaging to distinguish between recurrent brain tumors and radiation-induced tissue damage, which are hard to tell apart with standard MRI.
How Is the Trial Designed?
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Treatment groups
Experimental Treatment
Patients undergo advanced DR-CSI and sodium MRI over 30 minutes before SRS and 2 weeks, 3 months, and 6 months post-SRS. Patients also undergo clinical MRI on study.
Patients undergo advanced DR-CSI and sodium MRI over 30 minutes prior to SOC surgical resection or biopsy. Patients also undergo clinical MRI and tissue sample collection on study.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Jonsson Comprehensive Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
Citations
Advanced Magnetic Resonance Imaging in the Evaluation of ...
The NCCN recommends MRI immediately after surgery (up to 48–72 h), 2 to 8 weeks after RT, then every 2 to 4 months for 3 years, then every 3 to 6 months ...
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surgicalneurologyint.com
surgicalneurologyint.com/surgicalint-articles/advanced-magnetic-resonance-imaging-for-glioblastoma-oncology-radiology-integration/Advanced magnetic resonance imaging for glioblastoma
This study explores advanced MRI techniques better to understand GBM properties and their link to patient outcomes.
Advanced MRI increases the diagnostic accuracy of ...
Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion ...
A review of deep learning for brain tumor analysis in MRI
DL-based methods have achieved excellent results in segmenting larger structures, such as tentorium cerebelli, brain sinuses, or ventricles, ...
Monitoring Anti-angiogenic Therapy in Brain Tumors by ...
The purpose of this study is to predict treatment response to anti-angiogenic therapy in brain tumor participant using advanced MRI and MRS. MRI/MRS is an FDA- ...
NCT07339085 | Advanced Magnetic Resonance Imaging ...
Advanced MRI techniques like DR-CSI and sodium imaging may be effective in identifying the difference between recurrent brain tumors and RN.
Advanced magnetic resonance imaging for glioblastoma
Aggressive brain tumors like glioblastoma multiforme (GBM) pose a poor prognosis. While magnetic resonance imaging (MRI) is crucial for GBM ...
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auntminnie.com
auntminnie.com/clinical-news/mri/article/15681738/advanced-mri-neuroimaging-often-changes-brain-cancer-managementAdvanced MRI neuroimaging often changes brain cancer ...
Advanced neuroimaging MRI techniques -- such as perfusion and spectroscopy -- change 44% of management plans in patients with high-grade glioma, researchers ...
The Role of Advanced MR Imaging in Gliomas
Magnetic resonance imaging (MRI) is the modality of choice in the evaluation of intracranial tumors. The role of MRI in the workup of brain tumors can be ...
Advanced Magnetic Resonance Imaging Techniques in ...
Magnetic resonance imaging (MRI) is widely used in diagnosing brain metastases and differentiating them from other intracranial tumors. MRI is also used in ...
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