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MRI vs PET/CT for Diagnosing Brain Conditions

N/A
Waitlist Available
Led By Robert Young, MD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Pathological or clinical/radiological diagnosis of a neoplasm, either primary (e.g., malignant glioma) or secondary (metastasis from systemic malignancy) with a history of brain radiation therapy
Completed fractionated radiation therapy (to 60 Gy for high grade gliomas) or stereotactic radiosurgery or hypofractionated radiation therapy (e.g. for brain metastases, anaplastic meningiomas), without or with concurrent chemotherapy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial will examine whether MRI perfusion or PET/CT is better at distinguishing between growing tumors and radiation injury.

Who is the study for?
This trial is for adults over 18 with brain tumors or metastases who've had radiation therapy. They must have a new or growing lesion that's unclear if it's tumor growth or radiation injury. Participants can't be claustrophobic, allergic to MRI contrast dye, have contraindications to MRI like pacemakers, or be pregnant/nursing.Check my eligibility
What is being tested?
The study tests whether MRI perfusion scans (examining blood flow in the tumor) and PET/CT scans (checking for active tumor growth) can differentiate between a growing tumor and effects of radiation treatment. An optional advanced RSI scan may also be offered.See study design
What are the potential side effects?
There are generally no direct side effects from undergoing an MRI perfusion or PET/CT scan itself; however, some individuals might experience discomfort from lying still during the procedure or minor reactions to the contrast agent used in these imaging techniques.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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You have been diagnosed with a brain tumor and have received radiation therapy for it.
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You have finished a certain type of radiation therapy for brain cancer.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
imaging techniques
Secondary outcome measures
predicting tumor progression

Trial Design

1Treatment groups
Experimental Treatment
Group I: Pts with a brain tumorExperimental Treatment1 Intervention
The study will prospectively enroll patients who have increasing size and/or enhancement of brain lesion(s) after brain radiation therapy for a neoplasm (either primary or metastatic), where. it is unclear if a lesion represents radiation injury or progressive tumor. At the discretion of PI the RSI sequence may be repeated at SOC FDG or other radiotracer imaging carried out while the patient is still on study, if deemed clinically necessary.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MRI perfusion and PET/CT scans
2012
N/A
~150

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,928 Previous Clinical Trials
591,661 Total Patients Enrolled
Robert Young, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center
4 Previous Clinical Trials
509 Total Patients Enrolled

Media Library

MRI perfusion Clinical Trial Eligibility Overview. Trial Name: NCT01604512 — N/A
Brain Metastases Research Study Groups: Pts with a brain tumor
Brain Metastases Clinical Trial 2023: MRI perfusion Highlights & Side Effects. Trial Name: NCT01604512 — N/A
MRI perfusion 2023 Treatment Timeline for Medical Study. Trial Name: NCT01604512 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is access to this experiment available for those wishing to participate?

"Current reports on clinicaltrials.gov point to this trial being open for recruitment of patients. It was first posted on May 1st 2012 and has had its most recent update as June 1st 2022."

Answered by AI

How many medical centers are providing this clinical trial?

"Currently, this investigation is available at 6 different sites. These are primarily Harrison and Basking Ridge in New york but also include other nearby facilities to make it easier for participants to attend without having to travel too far."

Answered by AI

How many participants are being enrolled in this clinical experiment?

"Affirmative. Clinicaltrials.gov information indicates that this trial, posted on May 1st 2012 and most recently updated June 1st 2022, is actively seeking participants. The study requires 150 patients to be recruited from 6 sites around the country."

Answered by AI
~11 spots leftby Mar 2025