← Back to Search

Behavioural Intervention

Transcranial Magnetic Stimulation for Traumatic Brain Injury

N/A
Waitlist Available
Led By Paul F Pasquina, M.D.
Research Sponsored by Walter Reed National Military Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured to compare changes from baseline; during weeks 2, 4, 6 of treatment; and during the month 1, month 2, and month 3 follow up visits after treatment ends.
Awards & highlights

Study Summary

The overall objective of this project is to determine the efficacy and tolerability of TMS for mild Traumatic Brain Injury (mTBI) with PTSD symptoms and correlate treatment response with anatomical and biological factors unique to each service member (SM). Exploratory work will be done to look at the neuronal and biological changes that may occur over the course of TMS treatment.

Eligible Conditions
  • Traumatic Brain Injury
  • Post-Traumatic Stress Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured to compare changes from baseline; during weeks 2, 4, 6 of treatment; and during the month 1, month 2, and month 3 follow up visits after treatment ends.
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured to compare changes from baseline; during weeks 2, 4, 6 of treatment; and during the month 1, month 2, and month 3 follow up visits after treatment ends. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
PTSD Check List-Civilian (PCL-C)
Rivermead Post-Concussion Symptoms Questionnaire (RPQ)
Secondary outcome measures
Beck Scale for Suicide Ideation (BSS)
Mayo-Portland Adaptability Inventory-Military Edition (MPAI-m)
Mental Depression
+1 more
Other outcome measures
Automated Neuropsychological Assessment Metrics (ANAM)
Biomarker Assessment: Blood Samples
Biomarker Assessment: Saliva Samples
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Transcranial Magnetic StimulationExperimental Treatment1 Intervention
TMS sessions will consist of both 10Hz left pre-frontal stimulation for 3,500 pulses followed by 1Hz right pre-frontal stimulation for 1,500 pulses per session, for a total stimulation time of approximately one hour per session.
Group II: Sham Transcranial Magnetic StimulationPlacebo Group1 Intervention
Sham TMS treatments will be conducted five times a week for 5 consecutive weeks, followed by a tapering of three sessions during week 6 and two sessions during week 7.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial Magnetic Stimulation
2017
Completed Phase 4
~730

Find a Location

Who is running the clinical trial?

Center for Neuroscience and Regenerative Medicine (CNRM)FED
23 Previous Clinical Trials
5,307 Total Patients Enrolled
Walter Reed National Military Medical CenterLead Sponsor
138 Previous Clinical Trials
33,954 Total Patients Enrolled
Louis M French, Psy.DStudy ChairWalter Reed National Military Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Transcranial Magnetic Stimulation (TMS) to Treat mTBI and PTSD
2015. "Transcranial Magnetic Stimulation (TMS) to Treat mTBI and PTSD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02458521.
All > Tb > Transcranial Magnetic Stimulation
~6 spots leftby May 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top