Speed of Processing Training for Mild Cognitive Impairment (MCI)

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Kessler Foundation, East Hanover, NJ
Mild Cognitive Impairment (MCI)+5 More
Speed of Processing Training - Behavioral
Eligibility
18 - 65
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a technique designed to improve processing speed can help people with TBI.

See full description

Eligible Conditions

  • Mild Cognitive Impairment (MCI)
  • Traumatic Brain Injury (TBI)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Mild Cognitive Impairment (MCI)

Study Objectives

This trial is evaluating whether Speed of Processing Training will improve 1 primary outcome and 3 secondary outcomes in patients with Mild Cognitive Impairment (MCI). Measurement will happen over the course of Baseline (week 1), immediately post-intervention (week 7) and 3 months post-intervention.

Month 3
Perceived Deficits Questionnaire
Symbol-Digit Modalities Test
TBI Quality of Life, Depression scale
TBI Quality of Life, Total Score

Trial Safety

Safety Progress

1 of 3

Other trials for Mild Cognitive Impairment (MCI)

Trial Design

2 Treatment Groups

Treatment Group
1 of 2
Placebo control group
1 of 2
Experimental Treatment
Non-Treatment Group

This trial requires 80 total participants across 2 different treatment groups

This trial involves 2 different treatments. Speed Of Processing Training is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Treatment Group
Behavioral
Computerized exercised will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).
Placebo control group
Behavioral
Computerized exercises will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Speed of Processing Training
2011
N/A
~260

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline (week 1), immediately post-intervention (week 7) and 3 months post-intervention
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline (week 1), immediately post-intervention (week 7) and 3 months post-intervention for reporting.

Who is running the study

Principal Investigator
N. C.
Nancy Chiaravalloti, Director, Neuropsychology & Neuroscience; Director, Traumatic Brain Injury Research
Kessler Foundation

Closest Location

Kessler Foundation - East Hanover, NJ

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
diagnosis of Traumatic Brain Injury or Mild cognitive impairment
Fluent in English
processing speed impairment

Patient Q&A Section

What causes brain injuries?

"The cause of brain injuries is not understood. There are a number of putative exposures, including maternal health, perinatal factors, and lifestyle factors. Some environmental or toxic agents may have a role, though the evidence is preliminary. The mechanisms involved include altered brain development, prenatal immune activation, traumatic brain injury and ischemia, and encephalopathy." - Anonymous Online Contributor

Unverified Answer

What is brain injuries?

"Brain injuries are a major cause for prolonged hospital stay, disability, and financial burden, resulting in decreased quality of life for patients. Brain injuries can be caused by many external and internal factors. More research should be conducted to elucidate the mechanisms and risk factors for brain injuries due to the increasing number of people that suffer from brain injuries." - Anonymous Online Contributor

Unverified Answer

How many people get brain injuries a year in the United States?

"Based on the American Trauma Association estimate of 28,769 traumatic brain injuries a year in the United States, an estimated 508,000 TBIs will occur this year. This equates to 1.8 traumatic brain injuries per day in the United States." - Anonymous Online Contributor

Unverified Answer

Can brain injuries be cured?

"Brain injuries (traumas) are difficult to cure; however, rehabilitation can be made much more effective by working with the patient and his family in an ongoing medical/rehabilitation process. An individual's capacity to understand is a key element to success." - Anonymous Online Contributor

Unverified Answer

What are the signs of brain injuries?

"There is a wide range of clinical signs associated with brain injuries and neurologic impairment. These signs will affect all survivors of brain injuries and depend on the type of injury." - Anonymous Online Contributor

Unverified Answer

What are common treatments for brain injuries?

"In a recent study, findings of multiple studies reveal that neurosurgical management is efficacious in the treatment of TBIs. Rehabilitative treatments, such as Occupational Therapy Therapy (OTTH) and physical therapy are also used often and are important components of all TBI treatment models. Overall, research and clinical practice indicate that rehabilitation is the core element of TBI treatment, and has led to improvements in health care, overall quality of life, and return to work rates." - Anonymous Online Contributor

Unverified Answer

Has speed of processing training proven to be more effective than a placebo?

"SOP is more effective than an active placebo in reducing posttraining reaction time and improving reaction speed. It may also be more effective than a placebo for improving performance following an initial brief reaction time training." - Anonymous Online Contributor

Unverified Answer

Is speed of processing training typically used in combination with any other treatments?

"The speed of processing has the potential to be effective in facilitating learning in a variety of cognitive functions. Further study is suggested to compare speed of processing training as it relates to learning of complex spatial configurations, and more traditional approaches which use perceptual learning." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of brain injuries?

"The study demonstrated that trauma is the most common cause of TBI. Recent findings of this study also showed that the causes of TBI were different in different cities. There were more than one cause in the city of Isfahan (P=0.001) than in Tehran (P=0.012). The reasons for this might be the prevalence of traffic accidents in Tehran and Isfahan. Other factors might be the age of traffic accidents or other reasons. Moreover, the study has found that the most common causes of TBI in Tehran were: traffic accidents (56%), falls from/from above (14%) and assaults (4%)." - Anonymous Online Contributor

Unverified Answer

Does speed of processing training improve quality of life for those with brain injuries?

"In a recent study, findings demonstrate that SPP training is a promising intervention that may facilitate the rehabilitation of clients with complex chronic conditions such as brain injury." - Anonymous Online Contributor

Unverified Answer

Is speed of processing training safe for people?

"To minimize the risk from speed of processing training, the protocol used at this study involves the following: (i) participants use the protocol to self-administer the training, (ii) the protocol is followed, (iii) the self-programming session involves use of the control conditions on the first day, and (iv) the training is not repeated, until a post-training assessment is completed." - Anonymous Online Contributor

Unverified Answer

How serious can brain injuries be?

"There are many reasons to pursue medical and surgical management of [traumatic brain injury](https://www.withpower.com/clinical-trials/traumatic-brain-injury) (TBI) including survival, functional independence, and social recovery. The incidence of brain injury can be incredibly high. However, a significant percentage of these patients require prolonged mechanical ventilation and are considered to have a poor outcome. TBI is a complex condition that does not have one definite course of action but rather a multi-disciplinary plan for patients." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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