Study Summary
This trial will compare two different transfusion strategies for people with traumatic brain injury. The hypothesis is that a liberal transfusion strategy (transfusing at lower hemoglobin levels) will improve outcomes compared to a restrictive strategy.
- Traumatic Brain Injury
- Blood Transfusion
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 7 Secondary · Reporting Duration: 6 months
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Liberal Transfusion Strategy
1 of 2
Restrictive Transfusion Strategy
1 of 2
Experimental Treatment
742 Total Participants · 2 Treatment Groups
Primary Treatment: Red Blood Cells Transfusion · No Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 3 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Turgeon AF, Fergusson DA, Clayton L, Patton MP, Zarychanski R, English S, Docherty A, Walsh T, Griesdale D, Kramer AH, Scales D, Burns KEA, Boyd JG, Marshall JC, Kutsogiannis DJ, Ball I, Hébert PC, Lamontagne F, Costerousse O, St-Onge M, Lessard Bonaventure P, Moore L, Neveu X, Rigamonti A, Khwaja K, Green RS, Laroche V, Fox-Robichaud A, Lauzier F; HEMOTION Trial Team, the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group and the Canadian Traumatic Brain Injury Research Consortium. Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol. BMJ Open. 2022 Oct 10;12(10):e067117. doi: 10.1136/bmjopen-2022-067117.
- Turgeon AF, Fergusson DA, Clayton L, Patton MP, Zarychanski R, English S, Docherty A, Walsh T, Griesdale D, Kramer AH, Scales D, Burns KEA, Boyd JG, Marshall JC, Kutsogiannis DJ, Ball I, Hebert PC, Lamontagne F, Costerousse O, St-Onge M, Lessard Bonaventure P, Moore L, Neveu X, Rigamonti A, Khwaja K, Green RS, Laroche V, Fox-Robichaud A, Lauzier F; HEMOTION Trial Team, the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group and the Canadian Traumatic Brain Injury Research Consortium. Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol. BMJ Open. 2022 Oct 10;12(10):e067117. doi: 10.1136/bmjopen-2022-067117.
- Dr Alexis Turgeon 2017. "HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03260478.
Frequently Asked Questions
How many participants are registering for this research study?
"Affirmative, an examination of clinicaltrials.gov evinces that this medical trial is still looking for participants; it was initially announced on September 1st 2017 and the latest update occurred on August 16th 2022. The experiment hopes to recruit 742 patients from 19 different sites." - Anonymous Online Contributor
Where can participants find this research endeavor?
"This medical study is being administered at Centre Hospitalier de l'Université de Montréal in Hamilton, Ontario, Hamilton Health Sciences Center in Ottawa, Saskatchewan and The Ottawa Hospital in Regina, British Columbia as well as 19 other sites." - Anonymous Online Contributor