This trial is evaluating whether RT fMRI will improve 1 primary outcome and 4 secondary outcomes in patients with Traumatic Brain Injury (TBI). Measurement will happen over the course of 8 weeks.
This trial requires 150 total participants across 4 different treatment groups
This trial involves 4 different treatments. RT FMRI is the primary treatment being studied. Participants will be divided into 3 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.
"Brain injuries may be due to different types of trauma including accidents, blunt force and penetrating injuries and to other circumstances such as stroke and infectious, congenital or degenerative diseases. Damage to brain tissue is caused by changes to the cells that function in the brain. Damage to white matter can be caused by direct injury, e.g. penetrating trauma, or damage can be caused by changes to the blood supply to the brain, or by the breakdown of the blood–brain barrier. Changes to the blood supply can produce changes in the level of nutrients and removal of waste products. Damage to the cerebellum is often associated with ataxia but can result in other abnormalities such as hemiparesis and alexia." - Anonymous Online Contributor
"Bones or other surgically inserted implants may be the cause of many cases of chronic brain pain in young people. These brain injuries may be surgically repaired but there is no evidence that the results of the repairs can be long-term pain relief." - Anonymous Online Contributor
"The brain experiences the full impact of traumatic brain injury and is frequently a cause of permanent disabilities for individuals with multiple injuries in the process. The brain damage can arise from various causes, both natural and manmade, and can have a number of effects when it occurs.\n" - Anonymous Online Contributor
"The symptoms of brain injury should be considered, as a person may have symptoms such as visual field defects, an altered level of consciousness, amnesia, difficulty swallowing or talking and problems with concentration." - Anonymous Online Contributor
"There is no one cure for brain injuries. Brain injuries may need long-term treatment and can cause severe, debilitating or fatal complications. Commonly, treatment is supportive. Behavioral and cognitive therapies may help patients to maintain their skills and return to the normal activities. Neuroprotectants and neuroenhancers are useful to restore function after brain injuries. Surgery is often important in the management of brain injury but the outcome is dependent on the cause, extent and prognosis of brain injury." - Anonymous Online Contributor
"About 2 million people get a [brain injury](https://www.withpower.com/clinical-trials/brain-injury) each year; about 14% of these individuals suffer life-threatening health problems. The National Highway Traffic Safety Administration (NHTSA) reported the number of pedestrians and bicyclists killed by traveling vehicles to be 78,070 and 31,000, respectively in 1998. The number of pedestrian deaths is more than doubled to about 135,000 per year that same period. Although the injury rate of pedestrians has declined since the mid-1960s and has declined more than the motorcycle mortality rate, pedestrian fatalities are still the leading cause of unintentional vehicular deaths. The majority of walking deaths are still caused by children younger than 25 years of age." - Anonymous Online Contributor
"With rt fmri, participants do not have to be aware of the scanner or the scanner motion, and participants may not have to worry about overheating. Rt fmri can be used to screen for people at risk of brain injury, including in children and adolescents, those with recent stroke or severe brain injury, those in critical care, and those with focal neurological signs to the brain or those with a history of seizures." - Anonymous Online Contributor
"We found that although head injury patients with more severe injury, longer hospital stay and major disability are older and have worse outcomes than those with less serious injury, they still have good long-lasting functional outcomes on average." - Anonymous Online Contributor
"We found that fMRI is efficient for assessing quality of life in patients with brain injuries. It is also able to provide additional information when the EQ-5D-5L fails." - Anonymous Online Contributor
"Results from a recent clinical trial suggest that a genetic factor in the brain is important for the development of brain injuries, but that an environmental factor (such as alcohol) may be important in a small fraction of cases. However, more research is needed to investigate the biological or genetic factor underpinning brain injury." - Anonymous Online Contributor
"In summary, current research can not fully explain the cause of brain injuries and therefore cannot provide a satisfactory explanation of their treatment. Since research is continually improving, the current field of research is a good one to follow. However, we would advise that the readers of the literature should be vigilant to recognize the methodological limitations within the field. Clinicians should be aware of research developments to remain up to date and incorporate them in their treatment plans." - Anonymous Online Contributor
"Multiple causes of brain injuries contribute to the overall burden of this disabling condition. For many years, the underlying etiology of brain injuries has not been fully elucidated. In this review, we discuss the current research that contributes to our understanding of the many factors that can lead to brain injuries." - Anonymous Online Contributor