Blueberries for Weight Loss
Trial Summary
What is the purpose of this trial?
The objective is to complete a two-phase study to assess how wild blueberries impact regulation of appetite of overweight and obese men and women as well as to determine if wild blueberries can promote more effective weight loss than an isocaloric control. For phase I, the acute effects of consuming 1-cup of frozen wild blueberries mixed into ¾ C of low-fat yogurt will be compared to consuming an isocaloric serving of yogurt mixed with an artificially flavored and colored blueberry syrup. During acute testing, subjective ratings of appetite, glucose metabolism, and appetite-regulating hormones will be assessed. Phase II will consist of an 8-week feeding trial in which the same subjects will consume daily servings of yogurt mixed with either frozen wild blueberries or placebo syrup along with intensive counseling for weight loss. The hypothesis is that wild blueberries will reduce hunger by regulating appetite hormones and promoting beneficial glycemic and insulinemic responses and that daily consumption of wild blueberries will translate to improved adherence to a weight loss regimen and therefore greater weight and fat loss. Secondary aims for Phase II of this project will include exploring the impacts of blueberry consumption during weight loss on antioxidant status, inflammatory markers, blood lipid profiles, glucose status, dietary intake, physical activity and blood pressure.
Research Team
Shirin Hooshmand, PhD, RD
Principal Investigator
San Diego State University
Eligibility Criteria
This trial is for overweight or obese men and women with a Body Mass Index (BMI) between 25-40. It's designed to see if wild blueberries help control appetite and support weight loss when mixed into yogurt, compared to a placebo syrup.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Phase I - Acute Testing
Participants complete two acute feeding trials to assess the effects of wild blueberries on appetite and glucose metabolism.
Phase II - 8-week Feeding Trial
Participants consume daily servings of yogurt with either wild blueberries or placebo syrup, along with intensive counseling for weight loss.
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Impacts of Wild Blueberries on Appetite and Weight Regulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
San Diego State University
Lead Sponsor