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Non-invasive Brain Stimulation

30 min inter-session interval for Depression, Bipolar Disorder

N/A

Waitlist Available

Research Sponsored by University Health Network, Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, after each week of treatment (i.e. after 5 days of treatment), and 1, 4, and 12 weeks post-treatment. treatment will include 5 daily weekday visits over 4 weeks (20 sessions total).

Awards & highlights

Study Summary

This trial will compare the trajectories of improvement for three different patterns of twice-daily rTMS in major depression: two daily sessions of dorsomedial prefrontal rTMS delivered at 0 min vs. 30 min vs. 60 min intervals.

Eligible Conditions

Depression, Bipolar Disorder

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, after each week of treatment (i.e. after 5 days of treatment), and 1, 4, and 12 weeks post-treatment. treatment will include 5 daily weekday visits over 4 weeks (20 sessions total).

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, after each week of treatment (i.e. after 5 days of treatment), and 1, 4, and 12 weeks post-treatment. treatment will include 5 daily weekday visits over 4 weeks (20 sessions total).

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, after each week of treatment (i.e. after 5 days of treatment), and 1, 4, and 12 weeks post-treatment. treatment will include 5 daily weekday visits over 4 weeks (20 sessions total). for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

17-Item Hamilton Rating Scale for Depression (HAMD-17)

Secondary outcome measures

Beck Depression Inventory-II (BDI-II)

Trial Design

3Treatment groups

Experimental Treatment

Group I: 60 min inter-session intervalExperimental Treatment1 Intervention

Repetitive transcranial magnetic stimulation (rTMS) to bilateral dorsomedial prefrontal cortex, twice daily, 5 days per week for 4 weeks (Inter-session interval, 60 min).

Group II: 30 min inter-session intervalExperimental Treatment1 Intervention

Repetitive transcranial magnetic stimulation (rTMS) to bilateral dorsomedial prefrontal cortex, twice daily, 5 days per week for 4 weeks (Inter-session interval, 30 min).

Group III: 0 min inter-session intervalExperimental Treatment1 Intervention

Repetitive transcranial magnetic stimulation (rTMS) to bilateral dorsomedial prefrontal cortex, twice daily, 5 days per week for 4 weeks (Inter-session interval, 0 min).

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor

1,476 Previous Clinical Trials

485,000 Total Patients Enrolled

Centre for Addiction and Mental HealthOTHER

356 Previous Clinical Trials

81,278 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Recent research and studies

clinicaltrials.govStudy

Comparing Different Patterns of rTMS in Major Depression

2016. "Comparing Different Patterns of rTMS in Major Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02778035.

All > Major Depressive Disorder

~20 spots leftby Apr 2025

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