Wisdom Teeth Transplant for Tooth Loss

Overseen By Luis M De la Rosa, DDS

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Cleveland Dental Institute

Disqualifiers: Systemic diseases, Pacemakers, Allergies, Smokers, Periodontal diseases

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 3 Jurisdictions This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 1

Duration: 1 day

20 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Wisdom Teeth Transplant for Tooth Loss?

Research shows that autotransplantation, which involves moving a tooth from one spot in the mouth to another, has high success rates, often over 90%. It is a good option for replacing missing teeth, especially in young patients, and can lead to excellent functional and aesthetic outcomes. ^{1 2 3 4 5}

Is autotransplantation of teeth safe for humans?

Autotransplantation of teeth is generally considered safe when done properly, with high success rates reported in several studies. However, there is a risk of root resorption (breakdown of the tooth root) and other complications if the procedure is not performed correctly. ^{1 3 6 7 8}

How does the treatment of wisdom teeth transplant differ from other treatments for tooth loss?

Wisdom teeth transplant, or autotransplantation, is unique because it involves moving a natural tooth from one part of the mouth to another, providing a natural chewing feel and biological response without the need for artificial implants. This treatment is particularly beneficial for young patients with growing bone, offering a natural tooth replacement instead of a prosthetic or implant. ^{1 2 3 7 9}

What is the purpose of this trial?

Autotransplantation emerges as a viable alternative to tooth extraction and prosthetic restoration when conventional endodontic treatments are unfeasible or contraindicated. The success of autotransplantation is influenced by diverse factors, including root development stage, tooth morphology, surgical technique, extraoral duration, recipient socket shape, recipient bed vascularity, and periodontal ligament cell vitality. Preserving periodontal ligament quality and achieving tissue adaptation are pivotal for successful tooth transplantation. Successful donor tooth replacement is influenced by variables like fitting attempts, alveolus-root distance, extra-alveolar time, surgical skill, and extraction trauma intensity.

Research Team

Waleed Elmallah, DDS

Principal Investigator

Cleveland Dental

Ahmed Hashem, DDS

Principal Investigator

Cleveland Dental

Eligibility Criteria

This trial is for healthy adults aged 20-50 with immature wisdom teeth needing removal, who can follow study procedures and have no major health issues. It's not for those with systemic diseases affecting healing, pacemaker users, periodontal disease sufferers, medication allergy patients or active smokers.

Inclusion Criteria

I am between 20 and 50 years old.

I am either male or female.

Complying with the study procedures

Exclusion Criteria

I do not have any illnesses that could slow down my healing.

Patients with pacemakers

I have gum disease.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo autotransplantation of wisdom teeth, with or without Platelet Rich Fibrin

1 day

1 visit (in-person)

Follow-up

Participants are monitored for radiographic success of the transplanted teeth

52 weeks

Regular visits over one year

Treatment Details

Interventions

• Autotransplantation

Trial Overview The trial is testing the effectiveness of autotransplantation of wisdom teeth with and without Platelet Rich Fibrin (PRF), a substance that may aid healing. Participants will be randomly assigned to receive either just the tooth transplant or the transplant plus PRF.

Participant Groups

Group I: Autotransplantation with PRF Experimental Treatment 1 Intervention

Group II: Autotrasplantation only Active Control 1 Intervention

Autotransplantation is already approved in European Union, United States, Canada for the following indications:

Approved in European Union as Tooth Autotransplantation for:

• Tooth loss due to trauma
• Tooth loss due to decay
• Tooth loss due to periodontal disease
• Congenitally missing teeth

Approved in United States as Autogenous Tooth Transplantation for:

• Tooth loss due to trauma
• Tooth loss due to decay
• Tooth loss due to periodontal disease
• Congenitally missing teeth

Approved in Canada as Dental Autotransplantation for:

• Tooth loss due to trauma
• Tooth loss due to decay
• Tooth loss due to periodontal disease
• Congenitally missing teeth

Who Is Running the Clinical Trial?

Cleveland Dental Institute

Lead Sponsor

Trials

6

Recruited

440+

Findings from Research

Autogenous tooth transplantation can be a successful alternative for replacing lost teeth, as demonstrated in two cases where third molars were successfully transplanted into new sites after extraction, with follow-ups showing positive outcomes after 3 to 5 years.

The procedure involved careful surgical techniques and endodontic treatment, suggesting that with proper case selection and management, this method can provide both aesthetic and functional benefits, making it a cost-effective option compared to traditional prosthetics and implants.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Autogenous transplantation of teeth with complete root formation: two case reports. Teixeira, CS., Pasternak, B., Vansan, LP., et al.[2016]

Autogenous tooth transplantation is a successful method for replacing missing teeth in young patients, providing both functional and aesthetic benefits by using a natural tooth instead of artificial options.

A case report demonstrated a successful third molar transplantation to replace a first molar, with a follow-up period of 9 years, supporting the viability of this technique in modern dental practice.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Third Molar Autotransplantation: An Alternative to Dental Implant - 9 Years Follow up of a Case. Kumar, S., Jain, M., Sogi, S., et al.[2021]

Autogenous tooth transplantation has become a reliable option for tooth replacement, achieving high success rates when performed with careful patient selection and proper technique.

This procedure eliminates the need for implant-supported prosthetics, providing both aesthetic and functional benefits, as demonstrated in three case reports discussed in the article.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Autogenous tooth transplantation: an alternative to dental implant placement? Clokie, CM., Yau, DM., Chano, L.[2004]

Autotransplantation of teeth has favorable long-term survival rates and can provide benefits such as maintaining a functioning periodontium and preserving alveolar bone volume, especially in growing patients.

Despite its advantages, autotransplantation is not widely practiced outside of Scandinavian countries, and this review aims to highlight factors influencing its success and promote its recognition as a viable treatment option for compromised teeth.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Autotransplantation: a viable treatment option for adolescent patients with significantly compromised teeth. Ong, D., Itskovich, Y., Dance, G.[2018]

Dental autotransplantation can achieve a high success rate of over 90%, making it a reliable option for tooth replacement within the same patient.

In a case involving an 18-year-old patient, the successful autotransplantation of an immature third molar to replace a decayed first molar was attributed to the atraumatic surgical technique and the developmental stage of the donor tooth, with positive outcomes observed after 36 months.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Autotransplantation of a mature mandibular third molar as alternative to dental implant placement: Case report. Tagliatesta, L., Guerri, F., Moscone, S., et al.[2021]

Autotransplantation of a fully formed third molar can be a successful alternative to dental implants for patients missing teeth, provided that the surgical technique is performed correctly.

Even if the autotransplantation fails, dental implants can still be placed afterward, making this approach a flexible option for tooth replacement.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Autotransplantation: An Alternative to Dental Implants- Case Report With 4-Year Follow-Up. Kobayashi, T., Blatz, MB.[2019]

A case report demonstrated successful autogenous tooth transplantation of an impacted tooth into the site of a decayed tooth, with 18 months of follow-up showing excellent healing and stability of the transplanted tooth.

Despite potential risks like root resorption, the procedure can achieve a high success rate when donor teeth are properly selected and managed, making it a viable treatment option for replacing missing teeth.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Autotransplantation. Gupta, S., Goel, M., Sachdeva, G., et al.[2020]

In a study of 182 autotransplanted teeth, the procedure demonstrated a low failure rate of 4.5% over a follow-up period of 2 to 60 months, indicating its effectiveness as a treatment for missing teeth.

The success of the transplants was significantly influenced by initial stability, with those showing better stability achieving more complete healing, while the average extraoral time of 7.58 minutes did not correlate with complications like root resorption or ankylosis.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Evaluation of the prognosis and causes of failure in 182 cases of autogenous tooth transplantation. Kim, E., Jung, JY., Cha, IH., et al.[2022]

In a study involving over 20 patients, 90% of autotransplanted mandibular third molars were successful, demonstrating that this procedure is a viable option for replacing missing molars without immune reactions.

The study suggests that autotransplantation not only restores normal chewing function and periodontal healing but also presents a cost-effective alternative to other prosthetic rehabilitation methods.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

A Prospective Study on Autotransplantation of Mandibular Third Molars With Complete Root Formation. Dhar, S., Singh, G., Mishra, M., et al.[2023]

References

1. England pubmed.ncbi.nlm.nih.gov

Autogenous transplantation of teeth with complete root formation: two case reports. [2016]

2. India pubmed.ncbi.nlm.nih.gov

Third Molar Autotransplantation: An Alternative to Dental Implant - 9 Years Follow up of a Case. [2021]

3. Canada pubmed.ncbi.nlm.nih.gov

Autogenous tooth transplantation: an alternative to dental implant placement? [2004]

4. Australia pubmed.ncbi.nlm.nih.gov

Autotransplantation: a viable treatment option for adolescent patients with significantly compromised teeth. [2018]

5. India pubmed.ncbi.nlm.nih.gov

Autotransplantation of a mature mandibular third molar as alternative to dental implant placement: Case report. [2021]

6. United States pubmed.ncbi.nlm.nih.gov

Autotransplantation: An Alternative to Dental Implants- Case Report With 4-Year Follow-Up. [2019]

7. India pubmed.ncbi.nlm.nih.gov

Autotransplantation. [2020]

8. United States pubmed.ncbi.nlm.nih.gov

Evaluation of the prognosis and causes of failure in 182 cases of autogenous tooth transplantation. [2022]

9. United States pubmed.ncbi.nlm.nih.gov

A Prospective Study on Autotransplantation of Mandibular Third Molars With Complete Root Formation. [2023]