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Children with ASD for Autism Spectrum Disorder (PLAUSL Trial)

N/A
Recruiting
Led By Zhenghan Qi, MD/PhD
Research Sponsored by Northeastern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at the first visit during the school year of the first grade over a two-hour mri session
Awards & highlights

PLAUSL Trial Summary

The goal of this observational study is to test a reciprocal relationship between statistical learning and the development of language and literacy in first-graders with autism and their non-autistic peers. The main questions it aims to answer are: whether children's statistical learning abilities can predict their long-term improvement of language and literacy skills in school; how children's brains automatically learn patterns from speech and prints; whether children's learning in the lab reflects the language patterns they have learned over the years from their native language. First-grade students will participate in the study twice across three months. During Time 1, children will complete a battery of language, reading, and cognitive assessments a series of computer-based statistical learning games both inside and outside of functional MRI scanner. During Time 2, children will complete a battery of language and reading assessments to detect the growth in three months. Researchers will compare the autistic and the non-autistic groups to see if statistical learning plays a similar or different role in predicting children's language and literacy growth.

Eligible Conditions
  • Autism Spectrum Disorder
  • Language Development
  • Autism
  • Literacy

PLAUSL Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at the first visit during the school year of the first grade over a two-hour mri session
This trial's timeline: 3 weeks for screening, Varies for treatment, and at the first visit during the school year of the first grade over a two-hour mri session for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Language Composite Score
Language/Literacy Disorder Status
Neural similarity between language and statistical learning tasks
+3 more
Secondary outcome measures
Linguistic SL composite scores
Neural sensitivity to statistical regularities during the statistical learning tasks
Other outcome measures
Neural activation to statistical regularities during the language tasks

PLAUSL Trial Design

2Treatment groups
Experimental Treatment
Group I: Typically Developing ChildrenExperimental Treatment4 Interventions
Structural vs. Random sequences of stimuli; Intact vs. Degraded speech; Repeating 5-syllable nonwords or 2-syllable nonwords; Recall letter or syllable strings that either contain highly frequent bigram/trigram items or infrequent items according to English Corpus data
Group II: Children with ASDExperimental Treatment4 Interventions
Structural vs. Random sequences of stimuli; Intact vs. Degraded speech; Repeating 5-syllable nonwords or 2-syllable nonwords; Recall letter or syllable strings that either contain highly frequent bigram/trigram items or infrequent items according to English Corpus data

Find a Location

Who is running the clinical trial?

University of DelawareOTHER
154 Previous Clinical Trials
25,161 Total Patients Enrolled
1 Trials studying Autism Spectrum Disorder
46 Patients Enrolled for Autism Spectrum Disorder
Boston UniversityOTHER
454 Previous Clinical Trials
9,941,520 Total Patients Enrolled
3 Trials studying Autism Spectrum Disorder
155 Patients Enrolled for Autism Spectrum Disorder
Northeastern UniversityLead Sponsor
88 Previous Clinical Trials
61,260 Total Patients Enrolled
3 Trials studying Autism Spectrum Disorder
191 Patients Enrolled for Autism Spectrum Disorder

Frequently Asked Questions

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~29 spots leftby Aug 2024