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CO-OP Treatment Group for Autism Spectrum Disorder

N/A
Waitlist Available
Led By Jill G Zwicker, PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks (before and after intervention)
Awards & highlights

Study Summary

Developmental Coordination Disorder (DCD) is a neurodevelopmental disorder that affects a child's ability to learn motor skills, such as tying shoelaces, learning to print, or riding a bicycle (APA 2013). It often co-occurs with other conditions, such as Attention Deficit Hyperactivity Disorder (ADHD). Its high co-occurrence with Autism Spectrum Disorder (ASD) has only been permitted since 2013 so it is less well known. Recent neuroimaging studies have begun to unravel the neural underpinnings of each disorder; however, few brain imaging studies have included children with co-occurring DCD and ASD. The first aim of the proposed project is to understand brain structure and function in children with DCD+/-ASD. Despite high co-occurrence of DCD and ASD (Green 2009), motor impairment and functional problems are rarely the focus of therapy for children with ASD. Current best-practice for improving motor function is an approach called Cognitive Orientation to Occupational Performance (CO-OP). The second aim of this study is to examine effectiveness of this treatment approach for children with DCD+ASD and determine if there are brain changes and improvements in motor skills as a result of intervention. This novel project is the first to integrate brain imaging and motor-based rehabilitation in this population and builds on a current study examining brain changes in children with DCD (with and without co-occurring ADHD). Examining the neural basis of these motor difficulties in the presence or absence of co-occurring conditions will help to determine the neural correlates specific to DCD and whether the response to treatment differs in children with co-occurring conditions.

Eligible Conditions
  • Autism Spectrum Disorder
  • Motor Skills Disorder
  • Autism

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks (before and after intervention)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks (before and after intervention) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Canadian Occupational Performance Measure (COPM)
Diffusion Tensor Imaging on MRI
Secondary outcome measures
Bruninks-Oseretsky Test of Motor Proficiency 2nd ed. (BOT-2) short form
Performance Quality Rating Scale (PQRS)
Resting-state connectivity on MRI
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: CO-OP Treatment GroupExperimental Treatment1 Intervention
Participants in the treatment group will receive occupational therapy once weekly for 10 weeks using the published protocol for the CO-OP approach.
Group II: Waitlist Control GroupActive Control1 Intervention
Participants in the waitlist control group not receive CO-OP intervention during this time. They will receive their CO-OP intervention 12 weeks after their baseline assessment.

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,415 Previous Clinical Trials
2,466,986 Total Patients Enrolled
Waterloo FoundationUNKNOWN
3 Previous Clinical Trials
317 Total Patients Enrolled
Jill G Zwicker, PhDPrincipal InvestigatorUniversity of British Columbia

Frequently Asked Questions

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~5 spots leftby Apr 2025