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Procedure

Ablation for Atrial Fibrillation (COAST-AF RCT Trial)

N/A
Recruiting
Led By Pablo Nery, MD
Research Sponsored by Ottawa Heart Institute Research Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Subjects with symptomatic persistent AF AND clinically indicated catheter ablation for AF
Modified DR-FLASH score >=4
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 12 months and 18 months
Awards & highlights

COAST-AF RCT Trial Summary

This trial is testing whether adding atrial scar mapping to pulmonary vein isolation (PVI) is more effective than PVI alone in treating patients with persistent atrial fibrillation (AF).

COAST-AF RCT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have ongoing symptoms from atrial fibrillation and need a catheter ablation procedure for it.
Select...
Your DR-FLASH score is 4 or higher.

COAST-AF RCT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 12 months and 18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 12 months and 18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rate of documented (>30s) AF, atrial flutter or atrial tachycardia occuring from day 91 to 18 months post ablation
Secondary outcome measures
AF burden
Composite safety outcome
Incidence of any ECG documented AF with 90 days of ablation
+6 more

COAST-AF RCT Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Pulmonary Vein Isolation and scar ablationExperimental Treatment1 Intervention
Wide area circumferential catheter ablation for pulmonary vein isolation and scar ablation
Group II: Pulmonary Vein IsolationActive Control1 Intervention
Wide area circumferential catheter ablation for pulmonary vein isolation
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Catheter ablation
2016
Completed Phase 4
~810

Find a Location

Who is running the clinical trial?

Ottawa Heart Institute Research CorporationLead Sponsor
188 Previous Clinical Trials
92,072 Total Patients Enrolled
23 Trials studying Atrial Fibrillation
6,189 Patients Enrolled for Atrial Fibrillation
Heart and Stroke Foundation of CanadaOTHER
122 Previous Clinical Trials
71,707 Total Patients Enrolled
7 Trials studying Atrial Fibrillation
5,237 Patients Enrolled for Atrial Fibrillation
Pablo Nery, MDPrincipal InvestigatorOttawa Heart Institute Research Corporation
2 Previous Clinical Trials
2,000 Total Patients Enrolled
1 Trials studying Atrial Fibrillation
500 Patients Enrolled for Atrial Fibrillation

Media Library

Catheter ablation (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT03347227 — N/A
Atrial Fibrillation Research Study Groups: Pulmonary Vein Isolation and scar ablation, Pulmonary Vein Isolation
Atrial Fibrillation Clinical Trial 2023: Catheter ablation Highlights & Side Effects. Trial Name: NCT03347227 — N/A
Catheter ablation (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03347227 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment open for this research project yet?

"Affirmative, the details accessible via clinicaltrials.gov point to this medical trial being actively recruiting patients. It was established on August 24th of 2018 and has since been amended November 2nd 2021. A total of 502 participants are required for the 15 sites involved in the study."

Answered by AI

How many healthcare facilities are currently conducting this trial?

"This research endeavour is presently running in 15 different locations, including Sherbrooke, Toronto and Quebec City. To facilitate the process of enrollment it is best to select a clinic close to you so as to reduce any travelling needs."

Answered by AI

What is the upper limit of participants for this research endeavor?

"Correct. Clinicaltrials.gov data verifies that this trial, initially posted on August 24th 2018, is actively enrolling participants. 502 patients must be enrolled from 15 separate medical centres."

Answered by AI
~76 spots leftby Mar 2025