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Procedure

Anti-Arrhythmic Drug Therapy for Atrial Fibrillation (EARLY-AF Trial)

N/A
Waitlist Available
Led By Jason Andrade, M.D.
Research Sponsored by Jason Andrade
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 12, 24, and 36 months following treatment initiation
Awards & highlights

EARLY-AF Trial Summary

This trial is looking at whether a minimally invasive heart procedure is better than medication at preventing atrial arrhythmia recurrences.

EARLY-AF Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 12, 24, and 36 months following treatment initiation
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 12, 24, and 36 months following treatment initiation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Time to recurrence of symptomatic or asymptomatic Atrial Fibrillation, Atrial Flutter or Atrial Tachycardia
Secondary outcome measures
Economic Evaluation
Health-related quality of life
Healthcare utilisation
+6 more
Other outcome measures
Time to first episode of persistent atrial tachyarrhythmia

EARLY-AF Trial Design

2Treatment groups
Active Control
Group I: Anti-Arrhythmic Drug TherapyActive Control1 Intervention
Sinus rhythm control via the use of anti-arrhythmic drug (AAD) therapy ("first-line") based on local clinical practice, and according to guideline-suggested drug management for symptomatic patients with paroxysmal AF.
Group II: Cryoballoon-based PVIActive Control1 Intervention
Sinus rhythm control via a pulmonary vein isolation (PVI) ("first-line") procedure utilizing the the Arctic Front Cryoballoon Procedure.

Find a Location

Who is running the clinical trial?

Jason AndradeLead Sponsor
1 Previous Clinical Trials
135 Total Patients Enrolled
1 Trials studying Atrial Fibrillation
135 Patients Enrolled for Atrial Fibrillation
Baylis Medical CompanyIndustry Sponsor
9 Previous Clinical Trials
477 Total Patients Enrolled
3 Trials studying Atrial Fibrillation
235 Patients Enrolled for Atrial Fibrillation
Ottawa Heart Institute Research CorporationOTHER
188 Previous Clinical Trials
92,133 Total Patients Enrolled
23 Trials studying Atrial Fibrillation
6,388 Patients Enrolled for Atrial Fibrillation

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
New England Journal of MedicineJournal
Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation
Andrade, Jason G., George A. Wells, Marc W. Deyell, Matthew Bennett, Vidal Essebag, Jean Champagne, Jean-Francois Roux, et al.. 2021. “Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmoa2029980.
American Heart JournalJournal
A Randomized Clinical Trial of Early Invasive Intervention for Atrial Fibrillation (EARLY-AF) - Methods and Rationale
Andrade, Jason G., Jean Champagne, Marc W. Deyell, Vidal Essebag, Sandra Lauck, Carlos Morillo, John Sapp, et al.. 2018. “A Randomized Clinical Trial of Early Invasive Intervention for Atrial Fibrillation (EARLY-AF) - Methods and Rationale”. American Heart Journal. Elsevier BV. doi:10.1016/j.ahj.2018.05.020.
New England Journal of MedicineJournal
Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation
Andrade, Jason G., George A. Wells, Marc W. Deyell, Matthew Bennett, Vidal Essebag, Jean Champagne, Jean-Francois Roux, et al.. 2021. “Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmoa2029980.
clinicaltrials.govStudy
Early Aggressive Invasive Intervention for Atrial Fibrillation
Jason Andrade 2017. "Early Aggressive Invasive Intervention for Atrial Fibrillation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02825979.
~37 spots leftby Apr 2025
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