TSA Blueprint for Arthritis

Phase-Based Estimates
1
Effectiveness
1
Safety
Hôpital du Sacré-Cœur de Montréal, Montréal, Canada
Arthritis+1 More
TSA Blueprint - Procedure
Eligibility
18+
All Sexes
Eligible conditions
Arthritis

Study Summary

This study is evaluating whether a guide can improve the precision of glenoid implantation.

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Eligible Conditions

  • Arthritis
  • Shoulder Arthritis

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether TSA Blueprint will improve 1 primary outcome and 4 secondary outcomes in patients with Arthritis. Measurement will happen over the course of Before surgery.

2 weeks post-op
Radiological evaluation 1
2 years
Radiological evaluation 2
At surgery
Glenoid bone loss
Surgical time
Before surgery
Blood test

Trial Safety

Safety Estimate

1 of 3

Trial Design

4 Treatment Groups

TSA Standard
RTSA blueprint

This trial requires 112 total participants across 4 different treatment groups

This trial involves 4 different treatments. TSA Blueprint is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

RTSA blueprint
Procedure
This group will include patients schedule for a reverse total shoulder arthroplasty. Glenoid preparation will be done using the personalized guide provided by Wright-Tornier. This guide will be ordered after CT-scan measurement, using Blueprint software prior to surgery.
TSA blueprint
Procedure
This group will include patients schedule for a total shoulder arthroplasty. Glenoid preparation will be done using the personalized guide provided by Wright-Tornier. This guide will be ordered after CT-scan measurement, using Blueprint software prior to surgery.
TSA Standard
Procedure
This group will include patients schedule for a total shoulder arthroplasty. Glenoid preparation will be done following surgeon evaluation of the 2D CT scan with the institution software. Generic guides included in the regular instrumentation set will be used
RTSA standard
Procedure
This group will include patients schedule for a reverse total shoulder arthroplasty. Glenoid preparation will be done following surgeon evaluation of the 2D CT scan with the institution software. Generic guides included in the regular instrumentation set will be used

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 2 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 2 years for reporting.

Who is running the study

Principal Investigator
D. R.
Dominique Rouleau, Orthopaedic surgeon
Université de Montréal

Closest Location

Hôpital du Sacré-Cœur de Montréal - Montréal, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Patients with shoulder osteaoarthritis and AVN

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get arthritis a year in the United States?

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Around 50 million US adults suffer arthritis at some point in their lives, but 40% of them don't get diagnosed. Over 70 million could qualify for disability benefits right now.

Unverified Answer

What are common treatments for arthritis?

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Treatment priorities should be patient-centered and may entail all 4 of the following: addressing both the physical and psychological components of the disease, using an individualized approach to treatment, minimizing pain, taking into account the patient's comorbidities and considering the side effects of the prescribed medication.

Unverified Answer

What are the signs of arthritis?

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What is important is that you do not have pain immediately when you get out of bed or get in an elevator, but it will be a very long time before you feel pain in front of your knees (or any other place you get injured). Sometimes arthritis pain may feel like a dull constant ache. Often this is a normal part of the process of healing following an injury and may go away in a matter of days to months. The most important symptom of arthritis is pain which feels both like a "sting" and like a burning sensation. This sensation in your joints may vary over the course of the day.

Unverified Answer

Can arthritis be cured?

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It is difficult to establish the presence or absence of the disease in patients who are asymptomatic or have only mild arthritis. Although there is no known cure for RA or spondyloarthropathies, we found that asymptomatic arthritis patients with RA (and to a lesser extent, spondyloarthropathies), can become significantly better after treatment with DMARDs. These data suggest that the presence of RA should not preclude the use of DMARDs even in patients asymptomatic.

Unverified Answer

What causes arthritis?

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There is no absolute 'one cause' of arthritis. Causes are manifold. The common 'one cause' which is associated to almost all rheumatic diseases is a metabolic disorder, it is an accumulation of ama (undigested protein) in the musculoskeletal system. When this ama accumulates in the joints which may arise from lack of exercise and diet, it leads to the disease process. It may be observed in rheumatoid arthritis (RA), ankylosing spondylitis, reactive arthritis, and even juvenile idiopathic arthritis (JIA). The accumulation of this ama results in excessive release of inflammatory chemicals which lead to inflammation.

Unverified Answer

What is arthritis?

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Arthritis is a chronic inflammatory condition of joints, bones, cartilage and ligaments that can cause pain, swelling and disability. In the United States, arthritis is one of the most common health problems and costs about $200 billion each year, and results in more work absenteeism, disability, and hospitalization than just heart disease.

Unverified Answer

Does tsa blueprint improve quality of life for those with arthritis?

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Participants in the TA group reported greater improvements than the TA group in several key aspects of self-assessed quality of life. This difference was not sustained at a 3-month follow-up point, but highlights the potential benefits of TA as an add-on therapy to usual care. Future investigations are needed to better understand the magnitude of benefits of TA in reducing HRQOL measures in RA.

Unverified Answer

How does tsa blueprint work?

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There is no need for a separate tsa blueprint given that it is not supported by existing literature. There can be no doubt that patients will benefit from knowing their genetic information but a blueprint for tsa does not exist.

Unverified Answer

What is the average age someone gets arthritis?

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The average arthritis-free age appears to be around 40 years of age. However, those who have already had arthritis usually get it in their late teens or 20s.

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Is tsa blueprint typically used in combination with any other treatments?

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In a recent study, findings were encouraging. Using the blueprint seemed to be effective for improving quality of life and relieving symptoms. To be more effective, this method should be used in combination with other effective methods.

Unverified Answer

What is tsa blueprint?

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Tsa is the ultimate goal of rheumatoid arthritis as it is a disease which affects the life of an individual and the family he or she is living. In our life we face a lot of stress, pain and grief in a span of a lifetime. It is imperative that our wellbeing and quality of life are secured to meet our desired goals and expectations.

Unverified Answer

What is the primary cause of arthritis?

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The primary cause of arthritis does exist; it is not an elusive entity, but it is not the subject of most scientific inquiries. We see that for certain diseases, the primary cause is a virus (for instance, HIV), whereas for others, it is a bacterium (for instance, syphilis) or fungus (for instance, parvovirus B19, which causes arthritis in the immunocompromised), or maybe both a bacterium and a viremia (for instance, viral hepatitis) are the primary etiologs.

Unverified Answer
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Get access to this novel treatment for Arthritis by sharing your contact details with the study coordinator.