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Negative Work for Osteoarthritis (PTOA-ECC Trial)

N/A
Waitlist Available
Led By Michael Harris-Love, DSc
Research Sponsored by Washington D.C. Veterans Affairs Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

PTOA-ECC Trial Summary

The purpose of this study is to develop a negative work exercise regimen as an intervention for posttraumatic osteoarthritis (PTOA). "Negative work" is the force produced by muscles as they lengthen, and regularly occurs with common activities such as lowering an object from a shelf or walking down stairs. In this study, the investigators are examining the effectiveness of negative work exercise over a 12-week period in older, male, Veterans.

Eligible Conditions
  • Osteoarthritis
  • Arthritis

PTOA-ECC Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Maximum Voluntary Contraction (MVC; ft-lbs)
Muscle thickness (cm)
Secondary outcome measures
Knee injury and Osteoarthritis Outcome Score (KOOS; English version LK1.0)
Physical Performance Test (PPT-7)
Step Up/Over Test (movement time (s); kinetics (force indices)
+1 more

PTOA-ECC Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Negative WorkExperimental Treatment1 Intervention
Negative work exercise via isokinetic knee extension/flexion will be performed twice per week for 12 weeks.
Group II: StretchingPlacebo Group1 Intervention
A home exercise program consisting of stretches for the major lower extremity muscles groups will be performed twice per week for 12 weeks.

Find a Location

Who is running the clinical trial?

US Department of Veterans AffairsFED
868 Previous Clinical Trials
487,836 Total Patients Enrolled
13 Trials studying Osteoarthritis
4,655 Patients Enrolled for Osteoarthritis
Washington D.C. Veterans Affairs Medical CenterLead Sponsor
39 Previous Clinical Trials
17,983 Total Patients Enrolled
1 Trials studying Osteoarthritis
617 Patients Enrolled for Osteoarthritis
Michael Harris-Love, DScPrincipal InvestigatorWashington DC VA Medical Center
3 Previous Clinical Trials
66 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Negative Work Exercise for the Treatment of Knee Arthritis
Michael Harris-Love 2014. "Negative Work Exercise for the Treatment of Knee Arthritis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02098096.
All > Arthritis
~5 spots leftby Apr 2025
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