Evidence-Based Treatment for Primary Progressive Aphasia(PPA)

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Primary Progressive Aphasia(PPA)+4 More
Evidence-Based Treatment - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial will compare two types of speech language therapy to see which is more effective in treating mild Primary Progressive Aphasia. The study will last for 12 months and involve 5 evaluations and 15 therapy sessions, as well as access to a personalized web application. There is no cost to participate.

Eligible Conditions
  • Primary Progressive Aphasia(PPA)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

3 Primary · 0 Secondary · Reporting Duration: 5 assessment time points through study completion, an average of 1 year, including change over time

Year 1
Change in Communication Confidence PROM
Change in Communication Participation PROM
Change in Communication Participation Person Centered Goals
Change in Script accuracy (trained scripts)
Change in Word accuracy (trained words)

Trial Safety

Trial Design

2 Treatment Groups

Evidence-Based Impairment Focused
1 of 2
Communication Bridge™
1 of 2

Active Control

Experimental Treatment

95 Total Participants · 2 Treatment Groups

Primary Treatment: Evidence-Based Treatment · No Placebo Group · N/A

Communication Bridge™Experimental Group · 2 Interventions: Evidence-Based Treatment, Communication Bridge™ · Intervention Types: Behavioral, Behavioral
Evidence-Based Impairment FocusedActiveComparator Group · 2 Interventions: Evidence-Based Treatment, Evidence-Based Impairment Focused · Intervention Types: Behavioral, Behavioral

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 5 assessment time points through study completion, an average of 1 year, including change over time

Who is running the clinical trial?

National Institute on Aging (NIA)NIH
1,383 Previous Clinical Trials
3,447,504 Total Patients Enrolled
3 Trials studying Primary Progressive Aphasia(PPA)
1,680 Patients Enrolled for Primary Progressive Aphasia(PPA)
Northwestern UniversityLead Sponsor
1,432 Previous Clinical Trials
769,433 Total Patients Enrolled
5 Trials studying Primary Progressive Aphasia(PPA)
674 Patients Enrolled for Primary Progressive Aphasia(PPA)
Emily Rogalski, Ph.D.Principal Investigator - Northwestern University
Northwestern University
1 Previous Clinical Trials
70 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 9 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a neurological disorder that is consistent with PPA.
You are able to communicate in English.
You are able to pass the technology screening and demonstrate sufficient knowledge for use of the Communication Bridge™ web application.
You are 18 years of age or older.
You have adequate vision for reading a newspaper, or other functional materials (by self-report).
You have adequate hearing for communicating with others in a crowded room.
You have a score of at least 9 on the Geriatric Depression Scale.
You are able to pass the technology screening and demonstrate sufficient knowledge for use of the Communication Bridge™ web application.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 8th, 2021

Last Reviewed: November 30th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.