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tDCS + Speech-Language Therapy for Aphasia

N/A
Waitlist Available
Led By E. Susan Duncan, PhD, CCC-SLP
Research Sponsored by Louisiana State University and A&M College
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up following 8 weeks of speech-language therapy
Awards & highlights

Study Summary

This trial will test whether electrical brain stimulation, paired with standard speech-language therapy, can help people with aphasia (stroke-related language problems) recover lost language skills.

Who is the study for?
This trial is for individuals who have aphasia due to a single, unilateral stroke and can consent to participate. They must be able to undergo standard speech-language therapy. People with serious psychological, neurological (other than stroke), or medical conditions, pregnant women, those with a history of seizures, or with electronic/metal implants cannot join.Check my eligibility
What is being tested?
The study tests the effectiveness of anodal transcranial direct current stimulation (tDCS) versus sham (placebo-like) stimulation when combined with standard speech-language therapy on improving language abilities in people with aphasia from strokes.See study design
What are the potential side effects?
Potential side effects may include discomfort at the electrode site during tDCS, headache, fatigue, nausea or itching under the electrodes. Serious side effects are rare but could involve seizures or skin burns where the electrodes are placed.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~following 8 weeks of speech-language therapy
This trial's timeline: 3 weeks for screening, Varies for treatment, and following 8 weeks of speech-language therapy for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Production of Correct Information Units (CIUs) in Cinderella narrative
Secondary outcome measures
Communication Activities of Daily Living-2 (CADL-2)
Philadelphia Naming Test - Short Form (PNT)
Western Aphasia Battery-Revised (WAB-R)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: A-tDCS & speech-language therapyExperimental Treatment2 Interventions
Anodal transcranial direct current stimulation (2 mA) plus speech-language therapy for 16 sessions (20-minutes per each 60-minute treatment session) over the course of 8 weeks. The electrical current will be administered over ventral inferior frontal gyrus. The stimulation will be delivered at an intensity of 2mA for a maximum of 20 minutes.
Group II: Sham-tDCS & speech-language therapyPlacebo Group2 Interventions
Sham transcranial direct current stimulation (2 mA) plus speech-language therapy for 16 sessions (20-minutes per each 60-minute treatment session) over the course of 8 weeks. Electrodes will be placed as in A-tDCS. Current will be ramped up for the first 30 seconds following which the intensity will drop to 0 mA.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Anodal transcranial direct current stimulation
2016
Completed Phase 3
~140
Speech-language therapy
2017
N/A
~10

Find a Location

Who is running the clinical trial?

Louisiana State University and A&M CollegeLead Sponsor
9 Previous Clinical Trials
1,012 Total Patients Enrolled
1 Trials studying Aphasia
30 Patients Enrolled for Aphasia
E. Susan Duncan, PhD, CCC-SLPPrincipal InvestigatorLousiana State University
1 Previous Clinical Trials
30 Total Patients Enrolled
1 Trials studying Aphasia
30 Patients Enrolled for Aphasia

Media Library

Anodal transcranial direct current stimulation Clinical Trial Eligibility Overview. Trial Name: NCT03272906 — N/A
Aphasia Research Study Groups: A-tDCS & speech-language therapy, Sham-tDCS & speech-language therapy
Aphasia Clinical Trial 2023: Anodal transcranial direct current stimulation Highlights & Side Effects. Trial Name: NCT03272906 — N/A
Anodal transcranial direct current stimulation 2023 Treatment Timeline for Medical Study. Trial Name: NCT03272906 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment in this medical experiment available at the present time?

"According to clinicaltrials.gov, this trial is no longer in the recruitment phase as of September 15th 2021. Although it has closed its doors for now, there are still 1099 other trials actively seeking participants at present."

Answered by AI

Are there any age restrictions for enrolling in this experiment?

"The prerequisites to participate in this clinical trial are an age of 18 years or above and no more than 85."

Answered by AI

Do I meet the requirements for participating in this trial?

"This aphasia trial is accepting up to 7 individuals aged 18-85. To qualify for the study, patients must have sustained single, unilateral strokes and exhibit symptoms of aphasia."

Answered by AI

Who else is applying?

What state do they live in?
Utah
California
How old are they?
18 - 65
65+
What site did they apply to?
Louisiana State University
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Clinical Feasibility of Transcranial Direct Current Stimulation [tDCS] With Standard Aphasia Therapy
E. Susan Duncan 2017. "Clinical Feasibility of Transcranial Direct Current Stimulation [tDCS] With Standard Aphasia Therapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03272906.
~1 spots leftby Apr 2025
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