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Diagnostic Test

Patients with Elevated Gradients Post Transcatheter Aortic Valve Replacement for Aortic Stenosis (DISCORDANCE Trial)

N/A
Recruiting
Led By David Wood, MD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days
Awards & highlights

DISCORDANCE Trial Summary

The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.

Eligible Conditions
  • Aortic Stenosis
  • Aortic Valve Stenosis

DISCORDANCE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Patient-Prosthesis Mismatch (PPM) reclassification
Transaortic mean gradient reclassification
Transaortic valve gradients
+1 more
Secondary outcome measures
Risks of procedural complications
Total procedure time

DISCORDANCE Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients with Elevated Gradients Post Transcatheter Aortic Valve ReplacementExperimental Treatment1 Intervention
Patients who have an echocardiographic transaortic mean gradient ≥ 20mmHg OR VARC-3 criteria for ≥ moderate hemodynamic valve deterioration post TAVR on any TTE > 1 month post-TAVR

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,422 Previous Clinical Trials
2,468,212 Total Patients Enrolled
Edwards LifesciencesIndustry Sponsor
180 Previous Clinical Trials
62,340 Total Patients Enrolled
David Wood, MD2.718 ReviewsPrincipal Investigator - University of British Columbia
University of British Columbia
2 Previous Clinical Trials
311 Total Patients Enrolled
5Patient Review
He was very nice and understanding. He listened to everything I had to say and did a great job of explaining things. The staff was just as awesome.

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
David Wood 2021. "Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04827238.
~14 spots leftby May 2025
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