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Point of Care Ultrasound (POCUS)

Point of Care Ultrasound (POCUS) for Aortic Disease (AORTUS Trial)

N/A
Waitlist Available
Led By Luc Dubois, MD
Research Sponsored by London Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days
Awards & highlights

AORTUS Trial Summary

This trial will compare whether using ultrasound to guide fluid resuscitation after surgery is more accurate and feasible than usual care.

AORTUS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility - Contamination rate
Feasibility - POCUS Study completion
Feasibility - Protocol Adherence
+3 more
Secondary outcome measures
Feasibility - POCUS image quality

AORTUS Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Point-Of-Care Ultrasound Guided ResuscitationExperimental Treatment1 Intervention
Intervention in this trial is randomization to POCUS management for goal-directed post-operative resuscitation for the first 48 hours of admission.Patients randomized to the use of POCUS will have a focused cardiac, thoracic, and IVC study performed post-operatively in PACU, as well as regular (BID) assessments on the inpatient ward for post-operative day one and two. Based on ultrasound findings, their fluid resuscitation will be guided to a fluid liberal or fluid restrictive strategy at the time of each assessment.
Group II: Usual CareActive Control1 Intervention
The comparator arm in this trial is randomization to usual care. Participants randomized to control group for usual care will undergo resuscitation guided by modalities used currently, which can include both static and dynamic measures. These will include review of vital signs, biochemistry, and urine output as well as bedside physical exam. In this arm, patients will not undergo POCUS during their admission. IV fluid infusion rates as well as targets for IV boluses will be left to the discretion of the attending physician and can include hypotension, hypovolemia, as well as oliguria

Find a Location

Who is running the clinical trial?

London Health Sciences CentreLead Sponsor
142 Previous Clinical Trials
49,878 Total Patients Enrolled
Luc Dubois, MDPrincipal InvestigatorLondon Health Sciences Center

Frequently Asked Questions

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Recent research and studies
clinicaltrials.govStudy
Ultrasound-Guided Resuscitation in Open Aortic Surgery
Luc Dubois 2020. "Ultrasound-Guided Resuscitation in Open Aortic Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04180553.
~8 spots leftby Apr 2025
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