Ga-DOTATATE PETMRI scan for Aortic Aneurysm, Abdominal

Phase-Based Estimates
1
Effectiveness
1
Safety
University Health Network, Toronto, Canada
Aortic Aneurysm, Abdominal+3 More
Ga-DOTATATE PETMRI scan - DiagnosticTest
Eligibility
18+
All Sexes
Eligible conditions
Aortic Aneurysm, Abdominal

Study Summary

This study is evaluating whether a new imaging tool can improve the ability to predict growth of aneurysms.

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Eligible Conditions

  • Aortic Aneurysm, Abdominal
  • Aneurysm
  • Aortic Aneurysm
  • Abdominal Aortic Aneurysms (AAA)

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Compared to trials

Study Objectives

This trial is evaluating whether Ga-DOTATATE PETMRI scan will improve 1 primary outcome in patients with Aortic Aneurysm, Abdominal. Measurement will happen over the course of within 6 months after obtaining consent.

Month 6
68-Ga DOTATATE uptake

Trial Safety

Safety Estimate

1 of 3

Compared to trials

Trial Design

2 Treatment Groups

Control
Ga-DOTATATE PET/MRI scan

This trial requires 55 total participants across 2 different treatment groups

This trial involves 2 different treatments. Ga-DOTATATE PETMRI Scan is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Ga-DOTATATE PET/MRI scan
DiagnosticTest
Patients with abdominal aortic aneurysm will undergo Ga-DOTATATE PET/MRI scan
ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: within 6 months after obtaining consent
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly within 6 months after obtaining consent for reporting.

Closest Location

University Health Network - Toronto, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
patient subsequently dies The patient had an asymptomatic abdominal aortic aneurysm that was larger than 3 cm in diameter show original
At least 2 years before their ultrasound or CT imaging of their AAA, they must have had a minimum. show original
both are excellent imaging methods No contraindications to PET/MRI exist, such as claustrophobia; both are excellent imaging methods. show original
No prior treatment for AAA;
Age >50 years;

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of aortic aneurysm, abdominal?

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The following signs and symptoms are associated with AAA at an aneurysm stage above an aortic diameter of 5.5 cm: abdominal pain, weakness, backache, syncope in the absence of aortic instability, or loss of bowel or urinary function, or haematuria (i.e., blood in urine) in the absence of aortic instability.

Unverified Answer

Can aortic aneurysm, abdominal be cured?

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Even early surgery can reduce the risk of an aneurysmal death. Treatment with aortic vein occlusion or ascending aortic grafting for rupture, and surgery for aortic dissection can be curative in some respects. Even when the aorta is not patent, the risk of rupture is low, and is the same as the risk in untreated individuals.

Unverified Answer

What is aortic aneurysm, abdominal?

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Aortic aneurysms make up 3.6% of abdominal diagnoses in the USA and can be life-threatening. The risk of rupture increases with size and the presence of rAAV. Diagnostic procedures are difficult or impossible in patients with aneurysms smaller than 7 mm in diameter.

Unverified Answer

How many people get aortic aneurysm, abdominal a year in the United States?

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The rate of AAA progression is expected to increase as people live longer. The lifetime risk of AAA rupture will also increase with time as more people live longer and the risk for AAA progression remains constant. To reduce the number of AAA ruptures/dissections, more surveillance imaging should be done for patients at high risk and newer medicines should be tested for use in people with high-risk features.

Unverified Answer

What are common treatments for aortic aneurysm, abdominal?

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Treatment for aortic aneurysm is highly dependent on the type of aneurysm and how advanced the aneurysm is. The most common options include surgery, chemotherapy, radiation therapy, and targeted therapy.

Unverified Answer

What causes aortic aneurysm, abdominal?

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A number of factors including smoking, high BMI, poor physical fitness, high blood pressure and high plasma lipids are associated with an increased risk of aortic aneurysm. Aortic aneurysms are usually diagnosed and operated as a single disease but may result from multiple causes, sometimes reflecting a complex pathology.

Unverified Answer

How serious can aortic aneurysm, abdominal be?

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Patients with degenerative aortic aneurysm tend to be frail and are elderly. Aneurysms can compress adjacent organs and can cause pain and discomfort with exertion. Therefore, patients with degenerative aortic aneurysm will have decreased fitness. However, even so, it is important to note that a degenerative aortic aneurysm doesn't have to progress to rupture in order to cause death. This fact can be extrapolated to older patients with the disease.

Unverified Answer

What is the primary cause of aortic aneurysm, abdominal?

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Findings from a recent study shows that atherosclerosis and aortic aneurysm development have common origins and that atherosclerosis and aortic aneurysms are related to one another and to other aneurysmal disease such as thoracic aortic aneurysms. In view of how common atherosclerosis and aortic aneurysm are, and how devastating they can be, the development of medical screening for the aortic aneurysm should be strongly advocated, particularly for men who have had prior bypass surgery.

Unverified Answer

What is ga-dotatate petmri scan?

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The main advantage of the PET scan is that it allows visualization of vascular structures which cannot be seen with CT angiography or MRA. This imaging modality may be the preferred technique to assess vascular lesions in patients with aortic aneurysm and aortic dissection.

Unverified Answer

Does aortic aneurysm, abdominal run in families?

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An aortic aneurysm, abdominal run, phenotype in this large, population-based cohort was largely attributable to an inherited aortic aneurysm, rather than a family history of disease.

Unverified Answer

Has ga-dotatate petmri scan proven to be more effective than a placebo?

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Results from a recent clinical trial show that (99mTc)Ga-DOTA PET scan is a useful tool for assessing aortic and visceral wall changes. PET scan is more effective than PCTA, CT and MRI in demonstrating the presence of an abdominal aortic aneurysm.

Unverified Answer

How does ga-dotatate petmri scan work?

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The PET-CT scan with the single-plane method in combination with the acquisition of data at 1.5 tesla was shown to be a powerful technique for the assessment of abdominal aortic aneurysm with a high degree of accuracy.

Unverified Answer
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