This trial is evaluating whether Ga-DOTATATE PETMRI scan will improve 1 primary outcome in patients with Aortic Aneurysm, Abdominal. Measurement will happen over the course of within 6 months after obtaining consent.
This trial requires 55 total participants across 2 different treatment groups
This trial involves 2 different treatments. Ga-DOTATATE PETMRI Scan is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
The following signs and symptoms are associated with AAA at an aneurysm stage above an aortic diameter of 5.5 cm: abdominal pain, weakness, backache, syncope in the absence of aortic instability, or loss of bowel or urinary function, or haematuria (i.e., blood in urine) in the absence of aortic instability.
Even early surgery can reduce the risk of an aneurysmal death. Treatment with aortic vein occlusion or ascending aortic grafting for rupture, and surgery for aortic dissection can be curative in some respects. Even when the aorta is not patent, the risk of rupture is low, and is the same as the risk in untreated individuals.
Aortic aneurysms make up 3.6% of abdominal diagnoses in the USA and can be life-threatening. The risk of rupture increases with size and the presence of rAAV. Diagnostic procedures are difficult or impossible in patients with aneurysms smaller than 7 mm in diameter.
The rate of AAA progression is expected to increase as people live longer. The lifetime risk of AAA rupture will also increase with time as more people live longer and the risk for AAA progression remains constant. To reduce the number of AAA ruptures/dissections, more surveillance imaging should be done for patients at high risk and newer medicines should be tested for use in people with high-risk features.
Treatment for aortic aneurysm is highly dependent on the type of aneurysm and how advanced the aneurysm is. The most common options include surgery, chemotherapy, radiation therapy, and targeted therapy.
A number of factors including smoking, high BMI, poor physical fitness, high blood pressure and high plasma lipids are associated with an increased risk of aortic aneurysm. Aortic aneurysms are usually diagnosed and operated as a single disease but may result from multiple causes, sometimes reflecting a complex pathology.
Patients with degenerative aortic aneurysm tend to be frail and are elderly. Aneurysms can compress adjacent organs and can cause pain and discomfort with exertion. Therefore, patients with degenerative aortic aneurysm will have decreased fitness. However, even so, it is important to note that a degenerative aortic aneurysm doesn't have to progress to rupture in order to cause death. This fact can be extrapolated to older patients with the disease.
Findings from a recent study shows that atherosclerosis and aortic aneurysm development have common origins and that atherosclerosis and aortic aneurysms are related to one another and to other aneurysmal disease such as thoracic aortic aneurysms. In view of how common atherosclerosis and aortic aneurysm are, and how devastating they can be, the development of medical screening for the aortic aneurysm should be strongly advocated, particularly for men who have had prior bypass surgery.
The main advantage of the PET scan is that it allows visualization of vascular structures which cannot be seen with CT angiography or MRA. This imaging modality may be the preferred technique to assess vascular lesions in patients with aortic aneurysm and aortic dissection.
An aortic aneurysm, abdominal run, phenotype in this large, population-based cohort was largely attributable to an inherited aortic aneurysm, rather than a family history of disease.
Results from a recent clinical trial show that (99mTc)Ga-DOTA PET scan is a useful tool for assessing aortic and visceral wall changes. PET scan is more effective than PCTA, CT and MRI in demonstrating the presence of an abdominal aortic aneurysm.
The PET-CT scan with the single-plane method in combination with the acquisition of data at 1.5 tesla was shown to be a powerful technique for the assessment of abdominal aortic aneurysm with a high degree of accuracy.