Treatment for Chest Pain

Phase-Based Estimates
1
Effectiveness
1
Safety
Indiana University Health West Hospital, Avon, IN
Chest Pain+4 More
Eligibility
18+
All Sexes
Eligible conditions
Chest Pain

Study Summary

This study is evaluating whether three different anxiety treatments are effective.

See full description

Eligible Conditions

  • Chest Pain
  • Emergencies
  • Anxiety Disorders
  • Generalized Anxiety Disorder
  • Panic

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome and 8 secondary outcomes in patients with Chest Pain. Measurement will happen over the course of 12 months after enrollment.

12 months after enrollment
Adverse Cardiac Events
Anxiety Symptoms
Chest Pain
Depression symptoms
ED Utilization
Global Anxiety Change
Panic Symptoms
Physical Symptoms
Work/family/social functioning

Trial Safety

Safety Estimate

1 of 3

Trial Design

3 Treatment Groups

Therapist-Administered Cognitive Behavioral Therapy

This trial requires 375 total participants across 3 different treatment groups

This trial involves 3 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Therapist-Administered Cognitive Behavioral Therapy
Behavioral
Telehealth 8 one-hour sessions over the course of 8 to 10 weeks
Primary care follow-up
Behavioral
Enhanced primary care coordination
Online Cognitive Behavioral Therapy
Behavioral
Online Self-Administered Anxiety Management Program plus Peer Support Guidance

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 months after enrollment
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 12 months after enrollment for reporting.

Who is running the study

Principal Investigator
P. M.
Paul Musey, Director of Research
Indiana University

Closest Location

Indiana University Health West Hospital - Avon, IN

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
with a chief complaint of chest pain were prospectively enrolled from January 1, 2013, to December 31, 2013 From January 1, 2013, to December 31, 2013, adult emergency department (ED) patients (≥18yoa) presenting to the ED with a chief complaint of chest pain were prospectively enrolled. show original
in the next year A HEART Score of 0-3 indicates a Major Adverse Cardiac Event (MACE) risk equivalent to ≤2% in the next year. show original
Individuals with a "functionally" low risk status and a moderate HEART score of 4-6 should be evaluated with a diagnostic protocol, which should include at least two serial normal troponins spaced at least six hours apart, as well as cardiovascular stress testing in the observation unit. show original
If you are discharged from the emergency department within one week of your presentation, you will be screened again. show original
The patient comes in with chest pain, which leads to a standard of care diagnostic protocol to rule out possible acute coronary syndrome. show original
Moderate to severe anxiety as defined by a GAD-7 score ≥ 8 or a PHQ panic screener score ≥ 2
The patient is expected to be discharged from the emergency department or only undergo observation for less than 24 hours. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does chest pain run in families?

Add answer

Cardiac chest pain is a heterogeneous and familial disorder. It is commonly related to other cardiovascular diseases in patients with a positive family history of cardiovascular diseases. However, the inheritance of chest pain in patients without a family history appears to be more complex.

Unverified Answer

What causes chest pain?

Add answer

Many people have chest pain in the absence of heart attacks or other serious pathology. Causes include non-cardiac related diseases such as gastroesophageal reflux disease. Pain of chest pain is an important clinical problem with considerable health care cost, and for many people, there need may be no obvious underlying cause for what is triggering the pain.

Unverified Answer

What are common treatments for chest pain?

Add answer

Treatments are focused on the cause of chest pain; if the cause is not identifiable or if the cause is manageable, conservative options are chosen. If chest pain is due to a life-threatening condition such as a ruptured aortic aneurysm or a pulmonary embolism, immediate treatment with a blood thinner (blood transfusion) or hospital admission is needed. Patients who have undergone an angioplasty or stenting are more likely to have repeated angioplasty or stenting in the subsequent 6 months of follow-up. Aspirin has been recommended as first line therapy for acute coronary syndrome, and has also been found to be of benefit for other chest pain of non-cardiac origin.

Unverified Answer

How many people get chest pain a year in the United States?

Add answer

About 40 million Americans have at least one chest pain episode each year. The rate of chest pain is highest among African American and Hispanic persons, persons with low educational attainment, and persons aged 50 years and older.

Unverified Answer

Can chest pain be cured?

Add answer

There are many treatments which appear to be effective for symptoms of chronic chest pain. This article focuses on the treatment of chest pain as part of an overall approach to managing pain. It also attempts to answer two questions: (1) Is chest pain effectively treatable?; and (2) Is this treatment more effective than treatments currently applied in clinical practice? answer: There is evidence that many treatments can lower pain and pain-related symptom scores. The treatment of chest pain should be considered in terms of these factors together with patient characteristics and expectations.

Unverified Answer

What are the signs of chest pain?

Add answer

Chest pain affects about 15% of men and 1% of women. Signs of chest pain include coughing, shortness of breath, heaviness in the chest, and pressure-like pain or pressure on the center or bottom of the chest. Most severe chest pain is sudden. For pain that worsens and does not go away in a few days a cardiac emergency may be suspected.

Unverified Answer

What is chest pain?

Add answer

Chest pain is a condition in which patients experience pain in the chest, shoulder, or upper back, usually affecting the upper center of the chest and sometimes causing shortness of breath. Symptoms include chronic and severe pain. Although chest discomfort is a common symptom of coronary artery disease, other conditions such as heart attacks and lung diseases may be responsible. These include viral pneumonia, influenza, acute bronchitis, pneumothorax, and acute myocardial infarction (heart attack). Patients with chest pain may be asymptomatic, mildly symptomatic, or have severe symptoms. The diagnosis and treatment of chest pain is a complex and challenging issue. Treatment may require observation, medication, and imaging.

Unverified Answer

What is treatment?

Add answer

Patients who responded in a study to an anti-TNFalpha agent or to an anti-TNFalpha plus steroid were less willing than non-responders to be treated with medication. A better understanding and awareness of the possible clinical effects of the treatment may aid in minimizing treatment-induced side effects and in developing better personalized therapy regimens as well as in the selection of patients who are most likely to benefit.

Unverified Answer

What are the latest developments in treatment for therapeutic use?

Add answer

Currently, evidence supports the notion that the pathogenetic mechanisms of chest pain are multiple and complex. Although more studies are needed, recent advances in the field of electrophysiology help us to predict when and for how long we should treat chest pain of cardiac origin.

Unverified Answer

What is the latest research for chest pain?

Add answer

This resource will provide current clinical research literature, including recently published reviews, guidelines and expert opinions regarding diagnostic approaches and treatment-based management for chest pain. The reviews will serve as a resource for professionals and patients with a primary interest in clinical management of chest pain. Although the reviews will provide up-to-date, recent reviews, experts from the respective clinical areas will also be available for consultation to provide up-to-date opinions.

Unverified Answer

Have there been any new discoveries for treating chest pain?

Add answer

A large proportion of chest pain treatment research continues to focus on identifying the diagnosis instead of treatment. The quality of chest pain research also varies. We identify these gaps and discuss some strategies to build the foundation to advance chest pain treatment. Chest pain remains a serious, under-discussed, and highly visible health issue. It affects approximately 25% of the US population and is the number one cause of unexpected emergency room visits, visits to the emergency department (ED), and hospitalizations. The U.S. health care system spends an estimated $18 billion annually on chest pain research, of which nearly half is spent on developing new treatments and diagnostic tools. However, this is largely wasted.

Unverified Answer

What does treatment usually treat?

Add answer

Chest pain is common and most commonly felt as pain localised to the upper chest (epiglottitis). Patients who have experienced a history of chest pain may think to themselves, ‘I’ve had this kind of pain for so long and it stops now’. Treating pain can be very frustrating to patients as there are no options for curing chest pain. If the patient has experienced chest pain for longer than a year, the patient should visit their general practitioner to discuss their symptoms, and discuss the options available for treating it. Treatment options are based on the type and severity of the chest pain. The first thing that will be discussed is checking if there are any underlying issues that may be associated with chest pain.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Chest Pain by sharing your contact details with the study coordinator.