16 Participants Needed

The Use of LIFUP in Chronic Disorders of Consciousness

CS
JG
Overseen ByJeanette Gumarang, RN
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Casa Colina Hospital and Centers for Healthcare
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether LIFUP, a technique using sound waves to stimulate the brain, can help patients with chronic Disorders of Consciousness like Vegetative State or Minimally Conscious State. The goal is to see if this method can improve their awareness and responsiveness by targeting the thalamus. This technique has been studied for its potential to modulate brain activity non-invasively, showing promise in treating neurological conditions such as epilepsy and Parkinson's disease.

Will I have to stop taking my current medications?

If you are on a psychotropic medication regimen, you will need to keep it stable for at least 4 weeks before joining the study and remain on a stable regimen during the trial.

Who Is on the Research Team?

CS

Caroline Schnakers, PhD

Principal Investigator

Casa Colina Hospital and Centers for Healthcare

MM

Martin Monti, PhD

Principal Investigator

University of California, Los Angeles

Are You a Good Fit for This Trial?

Inclusion Criteria

Diagnosis of VS or MCS based on the CRS-R

Exclusion Criteria

You experience constant involuntary movements that would make it difficult to take images.
You are already participating in another research study.
You have a history of a neurological disorder, except for a brain injury.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a 10-day in-patient protocol involving LIFUP, EEG, PET, and polysomnography measurements

10 days
In-patient stay at Casa Colina Hospital

Follow-up

Participants are monitored remotely for safety and effectiveness after treatment

30 days
2 remote follow-up sessions at 7 and 30 days post-discharge

What Are the Treatments Tested in This Trial?

Interventions

  • BX Pulsar 1002 (LIFUP)
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Treatment LIFUPExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Casa Colina Hospital and Centers for Healthcare

Lead Sponsor

Trials
11
Recruited
350+

UCLA Department of Psychology

Collaborator

Trials
1
Recruited
20+

Tiny Blue Dot INC.

Collaborator

Trials
1
Recruited
20+

University of California, Los Angeles

Collaborator

Trials
1,594
Recruited
10,430,000+

Tiny Blue Dot Foundation

Collaborator

Trials
10
Recruited
660+
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