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Affect Treatment for Depression and Anxiety

N/A
Recruiting
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Willingness to refrain from starting other psychosocial or pharmacological treatments until study completion
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 5, week 10, post-treatment (week 16) and follow-up (week 20)
Awards & highlights

Study Summary

This trial is testing a new psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect, in the context of depression or anxiety. 100 participants will be enrolled and randomized to either Positive Affect Treatment or Negative Affect Treatment. The total length of participation is around 5 months.

Who is the study for?
This trial is for English-speaking adults aged 18-65 with depression or anxiety, low positive affect, and impaired functioning. They must not be using certain medications or have a history of substance abuse, bipolar disorder, psychosis, cognitive impairment, organic brain damage, or serious medical conditions. Smokers and pregnant individuals are excluded.Check my eligibility
What is being tested?
The study compares Positive Affect Treatment aimed at increasing reward sensitivity to Negative Affect Treatment focused on reducing threat sensitivity in people with depression/anxiety. Participants will undergo lab tests and assessments over approximately 5 months.See study design
What are the potential side effects?
Since this trial involves psychotherapy interventions rather than medication, typical side effects associated with drugs may not apply. However, participants might experience emotional discomfort during therapy sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I agree not to start any new mental health or drug treatments until the study ends.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 5, week 10, post-treatment (week 16) and follow-up (week 20)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 5, week 10, post-treatment (week 16) and follow-up (week 20) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Anxiety
Positive and Negative Affect Schedule Expanded (PANAS-X) (General Dimensions Scales)
Secondary outcome measures
Anxiety
Feeling suicidal (finding)
Behavioral Inhibition/Behavioral Activation (reward drive subscale) (BAS-RD)
+11 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Positive Affect TreatmentExperimental Treatment1 Intervention
15 sessions of psychotherapy designed to augment reward anticipation, reward attainment, and reward learning.
Group II: Negative Affect TreatmentActive Control1 Intervention
15 sessions of psychotherapy designed to decrease threat avoidance, threat appraisal and arousal.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Positive Affect Treatment
2019
N/A
~110

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,525 Previous Clinical Trials
10,279,638 Total Patients Enrolled
101 Trials studying Depression
48,343 Patients Enrolled for Depression
Southern Methodist UniversityOTHER
33 Previous Clinical Trials
5,773 Total Patients Enrolled
5 Trials studying Depression
881 Patients Enrolled for Depression

Media Library

Negative Affect Treatment Clinical Trial Eligibility Overview. Trial Name: NCT05203861 — N/A
Depression Research Study Groups: Positive Affect Treatment, Negative Affect Treatment
Depression Clinical Trial 2023: Negative Affect Treatment Highlights & Side Effects. Trial Name: NCT05203861 — N/A
Negative Affect Treatment 2023 Treatment Timeline for Medical Study. Trial Name: NCT05203861 — N/A
Depression Patient Testimony for trial: Trial Name: NCT05203861 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Do I meet the qualifications for participating in this research program?

"To qualify for this trial, individuals must be suffering from depression and should fall within the age range of 18 to 65. A maximum of 100 participants will be admitted."

Answered by AI

How many participants are eligible for this research project?

"Affirmative. According to clinicaltrials.gov, the trial has been open for recruitment since November 22nd 2021 and was recently updated on April 4th 2022. The research team is looking to enrol 100 participants from 2 medical sites."

Answered by AI

Is this research recruiting participants aged eighty-five or above?

"This medical experiment is open to all people aged 18-65 who seek to be included."

Answered by AI

Are there any open slots for enrollment in this scientific experiment?

"This research study is still gathering volunteers, as indicated on clinicaltrials.gov. It was first made available to the public on November 22nd 2021 and underwent its latest update on April 4th 2022."

Answered by AI

What aims does this experiment seek to accomplish?

"This study is designed to evaluate the impact of an intervention on Depression Anxiety and Stress Scale (DASS-21) over 16 weeks pre-treatment, 20 weeks post-treatment. Secondary outcomes include International Affective Picture System Task which assesses cardiac response to positive stimuli, Sheehan Disability Scale (SDS) that measures reported impairment due to symptoms with higher scores indicating greater disruption. This includes missed school/work days as well as reduced productivity., and Interviewer Anhedonia Ratings which rates interest and pleasure in hobbies/pastimes, foods/drinks, social activities with lower ratings indicative of more severe anhedonia."

Answered by AI

Who else is applying?

What state do they live in?
California
Louisiana
Texas
How old are they?
65+
18 - 65
What site did they apply to?
University of California, Los Angeles
Southern Methodist University
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
1
3+

Why did patients apply to this trial?

I've been on several other medications some worked for periods of time but now nothing is helping and I hope a clinical trial med can.
PatientReceived no prior treatments
I have tried many medications, types of therapy, being active, vitamins, etc for treatment and I still suffer and I want to see if something else might work. I also would like to be apart of something that could potentially help others. One of my main symptoms of depression is low affect.
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Southern Methodist University: < 24 hours
Average response time
  • < 1 Day
~7 spots leftby May 2024