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Affect Treatment for Depression and Anxiety
Study Summary
This trial is testing a new psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect, in the context of depression or anxiety. 100 participants will be enrolled and randomized to either Positive Affect Treatment or Negative Affect Treatment. The total length of participation is around 5 months.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- You have low positive feelings as measured by a test called PANAS-P, and you also have high scores for depression, anxiety, stress, and difficulties in daily life as measured by different tests.I agree not to start any new mental health or drug treatments until the study ends.You have a score of 5 or higher on any part of the Sheehan Disability Scale, which measures how much your daily life is affected by certain conditions.You smoke more than 11 cigarettes per week or use the equivalent amount of nicotine from other sources.I do not consent to being recorded on video or audio.You have a low level of positive emotions, and high levels of depression, anxiety, stress, and disability.You have a history of using marijuana, cocaine, or stimulants like amphetamines, cocaine, or methamphetamine, at least 5-7 times a week before you turned 15 years old.You have a low level of positive emotions, as measured by a specific questionnaire.You have used drugs or alcohol excessively in the past 6 months or have had a problem with addiction in the past year.You have had a history of bipolar disorder, psychosis, problems with thinking and memory, or brain damage.I have used bupropion or certain brain medications in the last 6 months.I do not have any serious, uncontrolled medical conditions.You agree not to use marijuana for one week before the medical tests.I am currently experiencing thoughts of harming myself.You are willing to refrain from starting psychosocial or pharmacological treatments until study completion.I have been on stable doses of certain anxiety or depression meds for 3 months.
- Group 1: Positive Affect Treatment
- Group 2: Negative Affect Treatment
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Do I meet the qualifications for participating in this research program?
"To qualify for this trial, individuals must be suffering from depression and should fall within the age range of 18 to 65. A maximum of 100 participants will be admitted."
How many participants are eligible for this research project?
"Affirmative. According to clinicaltrials.gov, the trial has been open for recruitment since November 22nd 2021 and was recently updated on April 4th 2022. The research team is looking to enrol 100 participants from 2 medical sites."
Is this research recruiting participants aged eighty-five or above?
"This medical experiment is open to all people aged 18-65 who seek to be included."
Are there any open slots for enrollment in this scientific experiment?
"This research study is still gathering volunteers, as indicated on clinicaltrials.gov. It was first made available to the public on November 22nd 2021 and underwent its latest update on April 4th 2022."
What aims does this experiment seek to accomplish?
"This study is designed to evaluate the impact of an intervention on Depression Anxiety and Stress Scale (DASS-21) over 16 weeks pre-treatment, 20 weeks post-treatment. Secondary outcomes include International Affective Picture System Task which assesses cardiac response to positive stimuli, Sheehan Disability Scale (SDS) that measures reported impairment due to symptoms with higher scores indicating greater disruption. This includes missed school/work days as well as reduced productivity., and Interviewer Anhedonia Ratings which rates interest and pleasure in hobbies/pastimes, foods/drinks, social activities with lower ratings indicative of more severe anhedonia."
Who else is applying?
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What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
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How responsive is this trial?
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Most responsive sites:
- Southern Methodist University: < 24 hours
Average response time
- < 1 Day
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