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Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus for Anhedonia (DEBRA Trial)

N/A
Waitlist Available
Led By Flavio Frohlich
Research Sponsored by University of North Carolina, Chapel Hill
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 hours
Awards & highlights

DEBRA Trial Summary

This trialtests a new brain stimulation technique to reduce depression and anhedonia symptoms.

Eligible Conditions
  • Anhedonia
  • Depression

DEBRA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percentage of trials that the participant chooses to perform the hard task
Secondary outcome measures
Coupling strength between low-frequency prefrontal signals and high-frequency posterior signals

DEBRA Trial Design

3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Delta-beta tACSExperimental Treatment1 Intervention
The study is investigating the use of transcranial alternating current stimulation (tACS). The stimulation is delivered at 1 milliampere (mA) zero-to-peak amplitude at the target electrodes and 2 mA zero to-peak amplitude at the return electrode. For the experimental arm, the tACS will be delivered using the cross-frequency stimulation waveform delta-beta (3-20Hz).
Group II: Theta-gamma tACSActive Control1 Intervention
This arm serves as an active control where tACS will be delivered using the cross-frequency stimulation waveform theta-gamma (5-50Hz).
Group III: Active-sham tACSPlacebo Group1 Intervention
For active sham stimulation, either delta-beta or theta-gamma stimulation is delivered for 10 seconds and then returns to baseline. This is intended to mimic the skin sensations (e.g., itching, burning, tingling) that are experienced at the onset of stimulation, assisting with blinding the participant's assignment.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus
2021
N/A
~70

Find a Location

Who is running the clinical trial?

University of North Carolina, Chapel HillLead Sponsor
1,504 Previous Clinical Trials
4,187,593 Total Patients Enrolled
3 Trials studying Anhedonia
276 Patients Enrolled for Anhedonia
National Institute of Mental Health (NIMH)NIH
2,783 Previous Clinical Trials
2,689,080 Total Patients Enrolled
17 Trials studying Anhedonia
1,807 Patients Enrolled for Anhedonia
Flavio FrohlichPrincipal InvestigatorUniversity of North Carolina, Chapel Hill
1 Previous Clinical Trials
23 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there a way for me to join this clinical trial?

"This clinical trial necessitates that participants have anhedonia and are between 18-65 years old. In total, 48 people may take part in the study."

Answered by AI

Are applicants younger than 85 years of age eligible to participate in this experiment?

"For this clinical trial, only adults aged between 18 and 65 may participate. For minors or those above senior age, there are 111 trials for the former group and 599 studies available to the latter cohort."

Answered by AI

How many participants is this clinical trial enrolling?

"Yes, the information available on clinicaltrials.gov points to this trial currently recruiting participants. Initially posted November 2nd 2021 and last edited October 21st 2022, 48 patients are needed for this study at a single site."

Answered by AI

Does this research endeavor currently have room for new participants?

"Affirmative. The information on clinicaltrials.gov supports that this medical research, published since November 2nd 2021, is now recruiting participants. A total of 48 individuals are needed to be enrolled from a single site."

Answered by AI

Who else is applying?

What state do they live in?
Oklahoma
North Carolina
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia
2021. "Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05084924.
~20 spots leftby Apr 2025
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