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Carbon Dioxide for Sickle Cell Anemia
Study Summary
This trial is looking at how blood flow and metabolism affects brain development in early life. SCA participants and healthy controls will have their blood flow and metabolism examined using MRI, and will also undergo cognitive assessments and brief questionnaires.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have sickle cell disease (Hb SS) or Sickle Beta-thalassemia.I am not taking any blood pressure-lowering medications like sildenafil or verapamil.I am between 4 and 21 years old.I sometimes have headaches but don't take daily medication for them.I have never had epilepsy.I can undergo an MRI scan without needing to be sedated.I am between 4 and 21 years old and healthy.I have never had a stroke or brain blood vessel issues.
- Group 1: Sickle Cell Anemia
- Group 2: Healthy Control
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the aggregate enrollment rate for this experiment?
"Affirmative. Records from the clinicaltrials.gov website show that this particular trial, initially posted on June 15th 2021, is actively looking for participants. 120 individuals need to be enrolled at 1 location."
Is enrollment for this research project currently available?
"According to the listings on clinicaltrials.gov, this study is still in need of participants; it was published on June 15th 2021 and its specifications were most recently updated on March 27th 2022."
May I participate in this clinical experiment?
"This clinical study is open to 120 candidates aged between 4 and 21, suffering from a range of neurological conditions. To qualify for enrolment, potential participants must not have experienced epileptic seizures in the past; be on any vasodilatory medication such as sildenafil or verapamil; nor should they currently pregnant or take regular preventative medications for headaches. Additionally, those with significant psychiatric diagnoses, history of strokes/cerebrovascular diseases may not partake either."
How is Sickle Cell Anemia traditionally treated?
"Sickle cell anemia is a therapeutic agent used to address post-operative respiration, stapedectomy, endoscopy and Hypoplastic Left Heart Syndrome."
Does this trial have any age-related restrictions for potential participants?
"Those under the age of 21 and over 4 years old can be included in this trial. Data from clinicaltrials.gov indicates that there are 314 trials for minors, and 328 specifically for patients aged 65 or older."
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