Clozapine for Schizophrenia
(REVISIT-C Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you can participate if you are currently medication-free or on any antipsychotic, except clozapine or long-acting injectables with a dosing interval of more than 30 days.
What data supports the effectiveness of the drug Clozapine for schizophrenia?
Clozapine is considered the most effective drug for managing treatment-resistant schizophrenia, showing significant improvement in symptoms compared to other second-generation antipsychotic drugs, especially in patients who have not responded well to at least two other antipsychotic medications.12345
Is clozapine safe for use in humans?
What makes the drug clozapine unique for treating schizophrenia?
What is the purpose of this trial?
This trial is testing whether clozapine can reduce violent behavior more effectively than usual treatments in adults with schizophrenia who have recently been violent. Clozapine helps by balancing brain chemicals to manage symptoms. The study will last for several months and include regular medical check-ups. Clozapine has been shown to reduce violent and aggressive behavior in patients with schizophrenia, especially those who are treatment-resistant.
Research Team
Ragy R Girgis, MD
Principal Investigator
New York State Psychiatric Institute
Eligibility Criteria
This trial is for adults with schizophrenia or schizoaffective disorder who have been violent recently. They must be medically stable, able to consent, and not on certain long-term medications. Pregnant women, those intolerant to clozapine, with serious medical conditions or high suicide risk are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive treatment with clozapine or treatment as usual (TAU) for 24 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Clozapine
- Treatment as Usual
Clozapine is already approved in United States, European Union for the following indications:
- Schizophrenia
- Borderline Personality Disorder
- Paranoid Disorder
- Schizophrenia
- Treatment-resistant schizophrenia
Find a Clinic Near You
Who Is Running the Clinical Trial?
New York State Psychiatric Institute
Lead Sponsor
National Institute of Mental Health (NIMH)
Collaborator