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Vitamin

Folic Acid Supplement [Phase 1] for Sickle Cell Anemia

N/A
Waitlist Available
Led By Crystal Karakochuk, PhD, RD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 36 weeks
Awards & highlights

Study Summary

This trial will test if too much folic acid is harmful to children with sickle cell disease.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~36 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 36 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Red Blood Cell Folate Concentration
Secondary outcome measures
Acute Pain Crises
Megaloblastic anemia
Plasma Unmetabolized Folic Acid Concentration
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Placebo [Phase 1]Experimental Treatment2 Interventions
Phase 1: Placebo for 12 weeks; Phase 2: Wash-out period (no supplement or placebo) for 12 weeks; Phase 3: Folic acid supplement (1 mg per day) for 12 weeks
Group II: Folic Acid Supplement [Phase 1]Experimental Treatment2 Interventions
Phase 1: Folic acid supplement (1 mg per day) for 12 weeks; Phase 2: Wash-out period (no supplement or placebo) for 12 weeks; Phase 3: Placebo for 12 weeks
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Folic Acid Supplement
2020
N/A
~40
Placebo
1995
Completed Phase 3
~2670

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,415 Previous Clinical Trials
2,466,985 Total Patients Enrolled
Crystal Karakochuk, PhD, RDPrincipal InvestigatorUniversity of British Columbia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Folic Acid Supplementation in Children With Sickle Cell Disease
Crystal Karakochuk 2020. "Folic Acid Supplementation in Children With Sickle Cell Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04011345.
~7 spots leftby Apr 2025
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