180 Participants Needed

Video Games + Perceptual Learning for Lazy Eye

RW
Overseen ByRoger W Li, OD, PhD
Age: Any Age
Sex: Any
Trial Phase: Academic
Sponsor: Nova Southeastern University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial involves adults and children with amblyopia practicing visual tasks or playing video games using their weaker eye. The goal is to improve vision by taking advantage of the brain's ability to adapt and change. By using their weaker eye over time, participants may see improvements in their visual abilities. Video games have been shown to be effective in improving vision and promoting brain adaptability in amblyopia treatment.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

Is the video game and perceptual learning treatment for lazy eye safe for humans?

The research does not report any safety concerns for video game and perceptual learning treatments for amblyopia (lazy eye), suggesting they are generally safe for humans.12345

How does the Video Games + Perceptual Learning treatment for lazy eye differ from other treatments?

This treatment is unique because it combines video game play with perceptual learning and dichoptic training, which involves using both eyes together to improve vision, unlike traditional methods that often focus on patching one eye. It offers a more engaging and potentially more effective approach to improving visual functions like visual acuity and stereoacuity, especially in older children and adults who may not respond well to conventional patching therapy.15678

What data supports the effectiveness of this treatment for lazy eye?

Research shows that video game-based perceptual learning can improve visual functions like stereoacuity (depth perception) in patients with amblyopia (lazy eye), even when traditional patching therapy is not effective. Studies indicate that these video games can enhance both binocular (using both eyes) and monocular (using one eye) vision, suggesting they could be a useful alternative or complement to traditional treatments.12569

Who Is on the Research Team?

RW

Roger W Li, OD, PhD

Principal Investigator

Nova Southeastern University College of Optometry

Are You a Good Fit for This Trial?

This trial is for both adults and children who have normal vision or amblyopia, commonly known as 'lazy eye', where there's a noticeable difference in visual sharpness between the eyes. People with any eye diseases or involuntary eye movement (nystagmus) cannot participate.

Inclusion Criteria

I have a difference in vision between my eyes.
My vision is either normal or I have a lazy eye.
My vision is either normal or I have a lazy eye.

Exclusion Criteria

I have an eye condition.
I experience involuntary eye movements.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in video games, perceptual learning tasks, or occlusion therapy for amblyopia

1-6 months
4-5 sessions per week

Follow-up

Participants are monitored for changes in stereoacuity, contrast sensitivity, positional acuity, and visual acuity

9 months

What Are the Treatments Tested in This Trial?

Interventions

  • Occlusion Therapy
  • Perceptual Learning
  • Video Game Vision Training
Trial Overview The study is testing new treatments for lazy eye by using video game vision training, perceptual learning exercises, and traditional occlusion therapy which involves covering the stronger eye to improve the weaker one.
How Is the Trial Designed?
3Treatment groups
Experimental Treatment
Active Control
Group I: Video GamesExperimental Treatment1 Intervention
Group II: Perceptual learningExperimental Treatment1 Intervention
Group III: Occlusion therapyActive Control1 Intervention

Occlusion Therapy is already approved in European Union, United States, Canada for the following indications:

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Approved in European Union as Occlusion Therapy for:
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Approved in United States as Patching Therapy for:
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Approved in Canada as Monocular Occlusion Therapy for:

Find a Clinic Near You

Who Is Running the Clinical Trial?

Nova Southeastern University

Lead Sponsor

Trials
103
Recruited
12,000+

Published Research Related to This Trial

A home-based perceptual learning program using random dot stimuli (RDS) significantly improved stereoacuity in 32 children aged 7 to 14 with a history of amblyopia, showing a median improvement of 50% compared to a control group.
The study demonstrated that this innovative game-based approach not only enhanced stereoacuity during the treatment but also maintained improvements over a 6-month period, suggesting its potential as an effective alternative to traditional occlusion therapies.
A Random Dot Computer Video Game Improves Stereopsis.Portela-Camino, JA., MartΓ­n-GonzΓ‘lez, S., Ruiz-Alcocer, J., et al.[2019]
A home-based dichoptic video game treatment for amblyopia was effective, with 13 out of 14 adult participants showing restored binocular perception and significant improvements in visual acuity and stereopsis after 10 to 30 hours of use.
Both anaglyphic and lenticular versions of the video game provided similar therapeutic benefits, indicating that the treatment can be conveniently adapted for at-home use without compromising efficacy.
The iPod binocular home-based treatment for amblyopia in adults: efficacy and compliance.Hess, RF., Babu, RJ., Clavagnier, S., et al.[2022]
In a study involving 25 children aged 8 to 18 with amblyopia, the use of a self-administered perceptual learning video game did not lead to significant improvements in visual function compared to traditional patching methods.
While no overall benefits were observed, better compliance with the perceptual learning therapy was associated with some positive outcomes, suggesting that increasing adherence to treatment might enhance effectiveness in future studies.
Short-term Perceptual Learning Game Does Not Improve Patching-Resistant Amblyopia in Older Children.Lee, YH., Maniglia, M., Velez, F., et al.[2021]

Citations

A Random Dot Computer Video Game Improves Stereopsis. [2019]
The iPod binocular home-based treatment for amblyopia in adults: efficacy and compliance. [2022]
Short-term Perceptual Learning Game Does Not Improve Patching-Resistant Amblyopia in Older Children. [2021]
An updated review about perceptual learning as a treatment for amblyopia. [2022]
Stereoacuity Improvement using Random-Dot Video Games. [2020]
Pilot Study Evaluating the Feasibility of Comparing Computer Game Play with Close Work During Occlusion in Children Aged 2-7 Years with Amblyopia. [2022]
New insights into amblyopia: binocular therapy and noninvasive brain stimulation. [2022]
A dichoptic custom-made action video game as a treatment for adult amblyopia. [2022]
Broad-based visual benefits from training with an integrated perceptual-learning video game. [2021]
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