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Lifestyle Intervention for Alzheimer's Prevention (POINTER Trial)

N/A
Waitlist Available
Led By Laura D Baker, PhD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Capacity to complete physical exercise
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2 years
Awards & highlights

POINTER Trial Summary

This trial will test if lifestyle changes can help protect memory and thinking in older adults.

Who is the study for?
This trial is for African American/Black, Native American, or Hispanic/Latinx individuals aged 60-79 with a low MIND diet score and suboptimal cardiovascular health. It's for those who are sedentary, have a family history of memory issues but no cognitive impairment themselves. Participants must live in the study area without extended travel plans and be willing to engage in lifestyle changes for at least two years.Check my eligibility
What is being tested?
The POINTER study tests whether lifestyle interventions like physical activity, cognitive exercises, dietary changes, and social engagement can protect against memory loss in older adults at risk. Participants will be randomly assigned to either a self-guided or structured program based on successful Finnish models.See study design
What are the potential side effects?
Since this trial involves lifestyle modifications rather than medications, side effects are not typical as with drug trials. However, participants may experience fatigue or muscle soreness from new exercise routines or digestive changes due to diet adjustments.

POINTER Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am able to perform physical exercises.

POINTER Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Global cognitive function
Secondary outcome measures
Clinical Dementia Rating-Sum of Boxes
Digital Clock Drawing Test (DCTClock)
Memory
+5 more

POINTER Trial Design

2Treatment groups
Experimental Treatment
Group I: Structured Lifestyle InterventionExperimental Treatment1 Intervention
Lifestyle modification program that involves participants completing structured activities that target diet, physical exercise, and intellectual and social stimulation.
Group II: Self-Guided Lifestyle InterventionExperimental Treatment1 Intervention
Lifestyle modification program that is developed by the participant to meet his/her specific needs.

Find a Location

Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor
1,231 Previous Clinical Trials
999,813 Total Patients Enrolled
Alzheimer's AssociationOTHER
89 Previous Clinical Trials
38,763 Total Patients Enrolled
Laura D Baker, PhDPrincipal InvestigatorWake Forest University Health Sciences
4 Previous Clinical Trials
3,992 Total Patients Enrolled

Media Library

Self-Guided Lifestyle Intervention Clinical Trial Eligibility Overview. Trial Name: NCT03688126 — N/A
Alzheimer's Disease Research Study Groups: Structured Lifestyle Intervention, Self-Guided Lifestyle Intervention
Alzheimer's Disease Clinical Trial 2023: Self-Guided Lifestyle Intervention Highlights & Side Effects. Trial Name: NCT03688126 — N/A
Self-Guided Lifestyle Intervention 2023 Treatment Timeline for Medical Study. Trial Name: NCT03688126 — N/A
Alzheimer's Disease Patient Testimony for trial: Trial Name: NCT03688126 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who is the targeted demographic for this medical experiment?

"This research project is accepting 2000 individuals with Alzheimer's disease between the ages of 60 and 79. Applicants must meet certain essential criteria, such as absence of cognitive decline (TICSm score >32), low MIND Diet score (MIND Diet Screener) and suboptimal cardiovascular health; they should also be sedentary and have a first-degree family history of memory impairment. Furthermore, this study particularly seeks African American/Black, Native American or Hispanic/Latinx race applicants aged 70 to 79 who live in areas where POINTER interventions will be administered, without travel plans outside their home region during trial participation."

Answered by AI

Do you accept participants in their thirties for this experiment?

"This trial's admission requirements stipulate that the age range for participants must be between 60 to 79. By contrast, there are 23 clinical trials available to those under 18 and 542 studies catered towards seniors older than 65 years old."

Answered by AI

Are there any openings for enrolment in this medical trial?

"Subsequent to consulting clinicaltrials.gov, it appears that this medical study is currently not seeking participants; the trial has been available since August 1st 2019 and was last modified on April 21st 2022. Even though there are no further openings for this survey, 552 other trials presently require subjects for their studies."

Answered by AI

What is the scope of this research project in terms of medical institutions?

"The research is being conducted in Sacramento, California (Northern California), Downers Grove, Illinois (North carolina) and ChicagoIllinois with the assistance of Advocate Aurora Health. In addition to this there are 7 additional sites which have been allocated for the trial."

Answered by AI

Who else is applying?

What state do they live in?
Texas
Illinois
How old are they?
18 - 65
What site did they apply to?
Chicagoland--Rush
Wake Forest University
Other
Chicagoland--Advocate Aurora Health
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
1
0

Why did patients apply to this trial?

I wish to avoid or delay possible symptoms. I know there is an answer. Still looking for it.
PatientReceived no prior treatments
Mother DX w Alzheimers, Father also with vascula? Dementia. I did a study about a year ago. I am struggling with words though most people don’t realize I have dementia—not even my physician. I don’t hide it from him. I will let him know. No one realizes I have dementia. I sound normal.. I forget words, don’t know for sure what day it is. I taught at DePaul. Want to be productive!! Hope a cure is found soon!!
PatientReceived 1 prior treatment

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Houston: < 24 hours
Average response time
  • < 1 Day
Recent research and studies
~229 spots leftby Dec 2024