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tDCS + Cognitive Training for Aging

N/A
Recruiting
Research Sponsored by University of Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Physically mobile
Age: 65 to 89 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to post test. post test will occur approximately two weeks following baseline.
Awards & highlights

Study Summary

This trial will investigate the effects of combining cognitive training with transcranial direct current stimulation (tDCS) in healthy older adults.

Who is the study for?
This trial is for healthy older adults aged 65 to 89 who are physically mobile, have working memory function in the lower three-quarters percentile, and can understand English. Exclusions include severe physical or neurological impairments, psychiatric illnesses, MRI contraindications like metal implants, unstable medical conditions, certain medications that interfere with tDCS effects, left-handedness due to brain lateralization concerns, and significant hearing or vision deficits.Check my eligibility
What is being tested?
The study tests how cognitive training (CT) can be improved when combined with transcranial direct current stimulation (tDCS) in older adults. It uses a precision dosing algorithm for tDCS to optimize neural plasticity and learning readiness by adjusting the electric current levels and electrode placement on participants' heads.See study design
What are the potential side effects?
Potential side effects of tDCS may include mild itching or tingling at the electrode sites during application, fatigue after treatment sessions, headache or nausea. However these tend to be mild and temporary.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can move around on my own.
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I am between 65 and 89 years old.
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My working memory is within the normal range according to a computer test.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to post test. post test will occur approximately two weeks following baseline.
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to post test. post test will occur approximately two weeks following baseline. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
N-Back working memory

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Optimized tDCS + Cognitive TrainingExperimental Treatment2 Interventions
A Soterix Clinical Trials Direct Current Stimulator will apply 20 minutes of up to 4.0mA direct current through two biocarbon rubber electrodes covered with at least 5mm-thick conductive electrode paste buffer, and placed over the optimized locations based on the international 10-20 system by using a combination of 10-20 EEG cap measurement and a stereotactic neuronavigation system. Stereotactic neuronavigation will be used as needed and may not be used on all participants.
Group II: Sham tDCS + Cognitive TrainingPlacebo Group2 Interventions
Sham stimulation is performed with the same device and all procedures will be identical except for the duration of stimulation. Participants will receive 30 seconds of up to 4 mA of direct current stimulation at the beginning of the session. Participants habituate to the sensation of tDCS within 30-60 seconds of stimulation. This procedure provides the same sensation of tDCS without the full duration of stimulation, making it a highly effective sham procedure.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
cognitive training
2020
N/A
~420
tDCS
2017
Completed Phase 2
~640

Find a Location

Who is running the clinical trial?

Soterix MedicalIndustry Sponsor
10 Previous Clinical Trials
342 Total Patients Enrolled
University of FloridaLead Sponsor
1,340 Previous Clinical Trials
715,655 Total Patients Enrolled
28 Trials studying Aging
3,352 Patients Enrolled for Aging

Media Library

cognitive training Clinical Trial Eligibility Overview. Trial Name: NCT05377411 — N/A
Aging Research Study Groups: Optimized tDCS + Cognitive Training, Sham tDCS + Cognitive Training
Aging Clinical Trial 2023: cognitive training Highlights & Side Effects. Trial Name: NCT05377411 — N/A
cognitive training 2023 Treatment Timeline for Medical Study. Trial Name: NCT05377411 — N/A
Aging Patient Testimony for trial: Trial Name: NCT05377411 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still opportunities to participate in this research protocol?

"The clinical trial in question, which was initially advertised on the 8th of August 2022 and most recently updated on July 7th 2022 is not recruiting patients at this time. Notwithstanding, there are 245 other research trials actively enrolling volunteers across the country."

Answered by AI

Is there an eligibility criteria for me to join this medical research?

"The study is actively seeking elderly patients aged between 65 and 89. Thus far, 40 individuals have been recruited to participate in the trial."

Answered by AI

Does this examination accept applicants of advanced age?

"This clinical trial stipulates that the minimum age for enrollment is 65, with a maximum upper limit of 89 years old."

Answered by AI

Who else is applying?

What state do they live in?
Georgia
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

Interested in brain research and dementia.
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

Can the computerized screening be done remotely?
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
SMART Stimulation: Precision Neuromodulation of Cognition in Older Adults
2023. "SMART Stimulation: Precision Neuromodulation of Cognition in Older Adults". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05377411.
~0 spots leftby Apr 2024
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