Calf Muscle Strengthening for Aging

MH
GM
Overseen ByGretchen Meyer, PhD
Age: 65+
Sex: Any
Trial Phase: Academic
Sponsor: Washington University School of Medicine
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to explore how calf muscle strengthening exercises can reduce damage and inflammation in the muscles of older adults. By focusing on the impact of fat within the muscle, researchers hope to understand how progressive resistance exercise (PRE) can improve muscle health with age. Ideal participants can commit to a 12-week, thrice-weekly virtual exercise program and handle wearing a weighted vest. As an unphased trial, this study offers participants the opportunity to contribute to groundbreaking research on muscle health in aging.

What prior data suggests that this calf muscle strengthening protocol is safe for older adults?

Research has shown that calf muscle strengthening exercises are generally safe for older adults. Studies have found that these exercises can boost muscle strength and balance without major risks. For example, one study discovered that doing calf-raise exercises at home improved nerve and muscle coordination in older men, which can help prevent mobility issues.

Another study suggested that heavy strength training, including calf muscle exercises, might even reduce heart-related risks in older adults. These exercises are designed to be safe and effective, focusing on building muscle strength.

Overall, evidence supports that calf muscle strengthening is well-tolerated and carries a low risk of side effects for older adults.12345

Why are researchers excited about this trial?

Researchers are excited about calf muscle strengthening exercises for aging because they offer a non-invasive, easily accessible method to improve muscle health in older adults. Unlike traditional treatments that might include medication or physical therapy in clinical settings, this approach leverages virtual group sessions over Zoom, making it convenient and potentially more engaging for participants. This method focuses directly on enhancing muscle strength and reducing fat within the muscle through consistent, guided exercises, which could lead to improved mobility and quality of life for the elderly.

What evidence suggests that calf muscle strengthening might be an effective treatment for aging?

Research has shown that strengthening the calf muscles greatly benefits older adults. This trial will focus on a calf muscle strengthening program, where participants will complete a 3x/week, 12-week exercise regimen over Zoom. One study found that performing calf-raise exercises at home improved the coordination between nerves and muscles, helping to prevent mobility issues. Another study demonstrated that these exercises enhanced walking and improved muscle health. Stronger calf muscles also correlate with better balance, which can help prevent falls. Overall, regular calf exercises can help older adults become stronger and improve their physical abilities.16789

Who Is on the Research Team?

GM

Gretchen Meyer, PhD

Principal Investigator

Washington University School of Medicine

Are You a Good Fit for This Trial?

Inclusion Criteria

Rapid Assessment of Physical Activity scores between 3 and 5
I can put on and take off a weighted vest by myself.
I have a smartphone and can use it for Zoom sessions.
See 1 more

Exclusion Criteria

Contraindications to radiation exposure (e.g. Women who are pregnant, previous high radiation exposure)
I am currently taking insulin, GLP1 agonists, hormone therapy, NSAIDs, anticoagulants, or statins.
I have leg problems or nerve issues that make exercise difficult.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks
2 visits (in-person)

Treatment

Participants undergo a 12-week progressive resistance exercise (PRE) program targeting the ankle plantarflexor, delivered via Zoom

12 weeks
3 sessions per week (virtual)

Follow-up

Participants are monitored for changes in muscle strength, composition, and biopsy results post-intervention

1 week
1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Calf muscle strengthening

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Calf muscle strengtheningExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Washington University School of Medicine

Lead Sponsor

Trials
2,027
Recruited
2,353,000+

National Institute on Aging (NIA)

Collaborator

Trials
1,841
Recruited
28,150,000+

Citations

Effect of calf-raise training on rapid force production ... - PMC

In conclusion, functional neuromuscular capacity can be enhanced by home-based calf-raise exercise in elderly men, which may protect against mobility loss with ...

Calf raise exercise increases walking performance in ...

Conclusions. Calf raise exercise improves walking performance and increases mitochondrial volume-density in the gastrocnemius muscle without increasing blood ...

Effectiveness of muscle strengthening and description ... - PMC

The literature currently shows that increasing lower limb muscle strength is effective for reducing the number of falls.

Do Strong Calves Help Prevent Falls?

– This study found that calf muscle strength is a significant predictor of balance performance in older adults, highlighting its importance in fall prevention.

Effectiveness of Home-Based Stretching and ...

Home-based resistance exercises using elastic bands have been shown to improve lean mass, strength, and muscle quality in older adults [10]. Eccentric exercise, ...

Heavy Strength Training in Older Adults - PMC

However, taken together, the data suggest that heavy‐very heavy strength training results in a lower cardiovascular risk than strength training ...

Calf-raise senior: a new test for assessment of plantar ...

The test can be a good indicator of ankle strength in older adults and proved to discriminate significantly between individuals with improved functionality.

Exercise interventions for older adults: A systematic review ...

The largest effect sizes for improvement were found for resistance training, meditative movement interventions, and exercise-based active videogames.

(PDF) Calf-raise senior: a new test for assessment of ...

Calf-raise senior: a new test for assessment of plantar flexor muscle strength in older adults: protocol, validity, and reliability. Taylor & ...