This trial is evaluating whether Colonoscopy 12 minute withdrawal will improve 1 primary outcome and 1 secondary outcome in patients with Colorectal Carcinoma (CRC). Measurement will happen over the course of Time of colonoscopy (day 1).
This trial requires 270 total participants across 3 different treatment groups
This trial involves 3 different treatments. Colonoscopy 12 Minute Withdrawal is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"Adenomas grow slowly, even on the same tissue type elsewhere in the GI tract. The risk factors associated with progression were age greater than 65 years, female sex, and race. In addition, the rate of progression was higher when the adenoma was large, was located in the right colon, or had progressed within the last 12 months." - Anonymous Online Contributor
"Recent findings show that adenoma progression is associated with changes in expression levels of genes involved in cell proliferation (PVRL3), intercellular signaling molecules (CDH1, PTK2, PIK3CA), extracellular matrix remodeling (MMP12, TIMP3), and apoptosis (CASP8, CASP10, BIRC5, BIRC6, and TRAIL). The expression profile of these genes is altered during the progression of adenomatous lesions. Furthermore, it appears that this alteration occurs early in the neoplastic process and precedes changes in cellular morphology, as well as the loss of E-cadherin." - Anonymous Online Contributor
"Adenoma is very common and benign and most often presents itself as an incidental finding during colonoscopy. For this reason, it is important to appreciate the characteristic features of adenoma on endoscopic examination. The main features of adenoma include:\n1. Tubular or villous architecture\n2. Mucosal folds\n3. Minimal or absent luminal narrowing\n4. Absence of inflammatory infiltrate\nTo improve detection of adenomas, it is important to learn how to look for them." - Anonymous Online Contributor
"There is not a statistically significant association between Barrett's esophagus with familial adenomatous polyposis. The presence of adenomas in families without BE suggests that other environmental factors play a role in determining susceptibility to BE in these individuals." - Anonymous Online Contributor
"Results from a recent clinical trial has shown that there is no increased risk of adenoma formation with short withdrawal times compared to standard withdrawal time (1 minute). Therefore, 12 minute withdrawal time for colonoscopy can be recommended." - Anonymous Online Contributor
"Adenoma is found at an increased rate in women with PCOS. Women with PCOS should be screened for the presence of adenoma, especially those over 50 years old. Women with a family history of colonic cancer have an elevated risk of adenoma. Colonoscopy is recommended every 5–10 years for all patients over 50 years old with a positive family history of colon cancer. Targeted screening is recommended for high-risk groups, including those with type 2 diabetes, obesity, and fasting insulin concentrations greater than 10 mIU/L." - Anonymous Online Contributor
"Adenomas affect all ethnic groups. They occur more frequently in men than women. The majority of adenomas are diagnosed incidentally at colonoscopy performed for other indications. Thus, we recommend checking the entire colon routinely for these lesions when they are found on screening colonoscopy." - Anonymous Online Contributor
"Adenoma has a good prognosis if the patient survives the initial surgery. To improve the survival rate, more intensive followup after surgery, coupled with early detection of recurrence and timely treatment, is warranted." - Anonymous Online Contributor
"Adenomas are common in the general population. Most of them will remain small, but some will become malignant. Poorly differentiated adenomas are more likely to become malignant than well-differentiated adenomas. Adenomas are associated with an increased risk for colorectal cancer. Thus, they should be removed when they can be safely removed." - Anonymous Online Contributor
"Adenomatous polyps are caused primarily by the presence of hereditary syndromes, but also by environmental factors such as smoking and diet. It is important to consider all possible causes of adenoma when diagnosing and treating these lesions." - Anonymous Online Contributor
"Adenomas are benign tumors found inside the colon and rectum. They do not grow into or invade anyone's organs, but they can produce the same type of symptoms as [colon cancer](https://www.withpower.com/clinical-trials/colon-cancer). Symptoms typically start between 40 and 60 years old. Unlike most cancers, adenomas tend to come back after being removed. A colonoscopy is recommended every two years to check for signs of any polyps or masses. If you notice any changes in your bowel habits, see your doctor immediately. [Power(http://www.withpower." - Anonymous Online Contributor