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Brachytherapy

Brachytherapy for Prostate Cancer

N/A

Waitlist Available

Led By Danny Song, M.D.

Research Sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial is testing a new system that will help place radioactive seeds in the prostate during brachytherapy, to refine the technical methods used, and to confirm the performance and accuracy of the system.

Eligible Conditions

Prostate Cancer

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Procedure Time

Secondary outcome measures

Dosimetric Accuracy Comparison Between Pre and Post Ultrasound (US) Implantation Prostate Edema

Impact of RUF System on Dosimetric Outcomes of Seed Placement as Assessed by Number of Patients With Prostate V100 of 95% or Greater

Mean Difference in D90 Between Intra-operative RUF and Standard CT/MRI Based Dosimetry

+4 more

Side effects data

From 2021 Phase 3 trial • 926 Patients • NCT01414608

79%

Fatigue

76%

Nausea

73%

Diarrhea

71%

Lymphocyte count decreased

65%

Anemia

36%

Vomiting

35%

Abdominal pain

31%

Vaginal discharge

31%

Platelet count decreased

28%

Pelvic pain

26%

Neutrophil count decreased

24%

Peripheral sensory neuropathy

22%

General disorders NOS

20%

Cystitis noninfective

17%

Alanine aminotransferase increased

16%

Pain in extremity

14%

Dermatitis radiation

12%

Creatinine increased

12%

Dehydration

11%

Vaginal pain

10%

Myalgia

10%

Hemorrhage Bladder

Aspartate aminotransferase increased

Hearing impaired

Proctitis

Vaginal dryness

Alopecia

Hemorrhage Rectum

Vaginal stricture

Mucositis oral

Thrombosis/Thrombus/Embolism

Urinary tract pain

Allergic reaction/ hypersensitivity

Rectal pain

Anal pain

Colitis

Lymphedema

Perineal pain

Telangiectasia

Enterocolitis

Febrile neutropenia

Female genital tract fistula

Peripheral motor neuropathy

Tumour pain

100%

80%

60%

40%

20%

Study treatment Arm

Standard Chemoradiation

Standard Chemoradiation With Adjuvant Chemotherapy

Trial Design

1Treatment groups

Experimental Treatment

Group I: Dynamic dosimetry brachytherapyExperimental Treatment1 Intervention

Cohort treated with dynamic dosimetry brachytherapy

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Brachytherapy

2007

Completed Phase 3

~2100

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Find a Location

Who is running the clinical trial?

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsLead Sponsor

558 Previous Clinical Trials

32,875 Total Patients Enrolled

56 Trials studying Prostate Cancer

3,303 Patients Enrolled for Prostate Cancer

Danny Song, M.D.Principal InvestigatorThe SKCCC at Johns Hopkins

3 Previous Clinical Trials

31 Total Patients Enrolled

2 Trials studying Prostate Cancer

25 Patients Enrolled for Prostate Cancer

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies available for participants in this experimentation?

"The information on clinicaltrials.gov reveals that this specific medical trial is not currently recruiting participants. Though it was originally posted in October 2014, and last updated in October 2022, there are a plethora of other trials which are presently enlisting patients."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Intraoperative Dosimetry for Prostate Brachytherapy Using Fluoroscopy and Ultrasound

2014. "Intraoperative Dosimetry for Prostate Brachytherapy Using Fluoroscopy and Ultrasound". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02225925.