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Ventilator for Critical Illness (IGNITE Trial)

N/A
Waitlist Available
Led By Robert L Owens, MD
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 hours
Awards & highlights

IGNITE Trial Summary

This trial will study the effects of different ventilator settings on patients with end-stage cardiac or respiratory failure who are receiving Extracorporeal Membrane Oxygenation (ECMO) therapy. The goal is to determine the best ventilator settings to minimize Ventilator Induced Lung Injury (VILI) and reduce the risk of multi-organ failure.

Eligible Conditions
  • Critical Illness
  • Acute Respiratory Distress Syndrome
  • Heart Failure
  • Extracorporeal Membrane Oxygenation
  • Respiratory Failure
  • Kidney Failure
  • Lung Disease

IGNITE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in plasma IL-6 level from baseline to low driving pressure ventilation
Secondary outcome measures
Change in plasma sRAGE from baseline to low driving pressure ventilation

IGNITE Trial Design

1Treatment groups
Experimental Treatment
Group I: Low Driving Pressure ProtocolExperimental Treatment1 Intervention
The patients ventilator driving pressure will be decreased (as tolerated by the patient) for 2 hours while on extracorporeal membrane oxygenation (ECMO) support.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ventilator
2011
N/A
~510

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,120 Previous Clinical Trials
1,521,327 Total Patients Enrolled
2 Trials studying Critical Illness
78 Patients Enrolled for Critical Illness
Robert L Owens, MDPrincipal InvestigatorUCSD
2 Previous Clinical Trials
54 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research endeavor taking on new participants?

"Unfortunately, according to clinicaltrials.gov this trial is not accepting patients at the moment. The experiment was first published on April 14th 2020 and last modified on March 4th 2022. Despite that, there are 1271 other trials actively recruiting participants as of now."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients
Robert L. Owens 2020. "Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04669444.
All > Ecmo
~16 spots leftby Apr 2025
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