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Nudges for Respiratory Distress (INPUT Trial)

N/A

Waitlist Available

Led By Meeta Kerlin, MD, MSCE

Research Sponsored by University of Pennsylvania

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through time of hospital discharge, average of 264 hours

Awards & highlights

INPUT Trial Summary

This trial will test whether EHR-based interventions can increase the use of lung-protective ventilation among all mechanically ventilated patients in 12 ICUs.

Who is the study for?

Adults over 18 who are admitted to one of the participating ICUs and require mechanical ventilation can join. It's not for those whose mechanical ventilation lasts less than 12 hours, only want comfort care in the first 72 hours, lack a recorded height or are under 4 feet tall, or are on minimal ventilator settings.Check my eligibility

What is being tested?

The study tests strategies to get doctors and respiratory therapists to use lung-protective ventilation (LPV) more often with adult patients on ventilators. It compares usual care with new prompts integrated into electronic health records across multiple ICUs.See study design

What are the potential side effects?

Since this trial focuses on implementing best practices rather than testing new medications, side effects relate primarily to potential issues from LPV like discomfort or inadequate oxygenation if not properly adjusted.

INPUT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through time of hospital discharge, average of 264 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through time of hospital discharge, average of 264 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and through time of hospital discharge, average of 264 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

fidelity to LPV

sustainability

Secondary outcome measures

Duration of time exposed to plateau pressure (Pplat)>30 mmHg

ICU length of stay

Total duration of exposure to tidal volume >8 cc/kg and >10 cc/kg IBW

+7 more

INPUT Trial Design

5Treatment groups

Active Control

Placebo Group

Group I: Physician-targeted accountable justification + RT-targeted accountable justificationActive Control2 Interventions

This arm will have the default order set and respiratory therapist-targeted accountable justification

Group II: Default order set + physician-targeted accountable justificationActive Control2 Interventions

This arm will have the default order set and physician-targeted accountable justification

Group III: Default order setActive Control1 Intervention

This arm will have the default order set implementation strategy

Group IV: Physician-targeted accountable justificationActive Control1 Intervention

This arm will have the physician-targeted accountable justification implementation strategy

Group V: Standard of CarePlacebo Group1 Intervention

This arm will have no interventions and standard of care practices will be in place.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor

2,000 Previous Clinical Trials

42,873,147 Total Patients Enrolled

9 Trials studying Critical Illness

9,135 Patients Enrolled for Critical Illness

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,834 Previous Clinical Trials

47,303,694 Total Patients Enrolled

18 Trials studying Critical Illness

14,192 Patients Enrolled for Critical Illness

Meeta Kerlin, MD, MSCEPrincipal InvestigatorUniversity of Pennsylvania

Media Library

Standard of Care Clinical Trial Eligibility Overview. Trial Name: NCT04663802 — N/A

Critical Illness Research Study Groups: Standard of Care, Physician-targeted accountable justification + RT-targeted accountable justification, Default order set + physician-targeted accountable justification, Default order set, Physician-targeted accountable justification

Critical Illness Clinical Trial 2023: Standard of Care Highlights & Side Effects. Trial Name: NCT04663802 — N/A

Standard of Care 2023 Treatment Timeline for Medical Study. Trial Name: NCT04663802 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the principal objective of this clinical research endeavor?

"The overarching goal of this trial is to assess the feasibility and sustainability over 72 hours. Additional objectives include measuring hospital length of stay, duration exposed to plateau pressure (Pplat) greater than 30 millimeters mercury, and total duration exposed to tidal volumes larger than 8 and 10 cc/kg ideal body weight."

Answered by AI

Are any spots still available for this clinical research endeavor?

"Per the well-regarded clinicaltrials.gov, this research study is presently accepting participants; its inaugural post was on February 22nd 2021 and it underwent an amendment as recently as June 30th 2022."

Answered by AI

How many participants are currently enrolled in this clinical trial?

"Affirmative. The information available on clinicaltrials.gov implies that this medical study is currently seeking participants, which was originally posted in February 22nd 2021 and last updated June 30th 2022. This trial requires 15100 patients at 5 designated locations across the country."

Answered by AI

Could I be considered as a potential subject for this medical experiment?

"In order to qualify for this medical research, participants must be between 18 and 99 years old with a serious health condition. The study is currently recruiting upwards of 15100 patients."

Answered by AI

Does the protocol for this research accept participants over eight decades of age?

"The study is open to participants aged between 18 and 99. Specifically, 102 studies are underway for individuals under the age of majority, while 424 trials target seniors over 65 years old."

Answered by AI

Recent research and studies

Implementation ScienceJournal

Implementing Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT): A Stepped-wedge, Hybrid Type III Trial of Strategies to Improve Evidence-based Mechanical Ventilation Management

Kerlin, Meeta Prasad, Dylan Small, Barry D. Fuchs, Mark E. Mikkelsen, Wei Wang, Teresa Tran, Stefania Scott, et al.. 2021. “Implementing Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT): A Stepped-wedge, Hybrid Type III Trial of Strategies to Improve Evidence-based Mechanical Ventilation Management”. Implementation Science. Springer Science and Business Media LLC. doi:10.1186/s13012-021-01147-7.

clinicaltrials.govStudy

Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study

2021. "Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04663802.