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Skin Conductance Metrics for Fear of Pain
N/A
Recruiting
Led By Fred A Lenz, MD PhD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Man or woman between 18 and 80 years of age
Possess ability to understand study procedures and comply with them for the entire length of the study
Timeline
Screening 3 weeks
Treatment Varies
Follow Up the whole duration of the study up to 5 years
Awards & highlights
Study Summary
This trial will study how people with job-related pain form expectations of pain and how this affects their disability. Results may lead to better diagnosis/management of PTSD & anxiety disorders.
Who is the study for?
This trial is for English-speaking adults aged 18-80 who are undergoing seizure monitoring at Hopkins Hospital and can follow the study's procedures. Women of childbearing age must use birth control. It excludes those with unstable neurological or psychiatric conditions, significant neuropsychological test abnormalities, abnormal MRI (except specific variants), pregnant women, non-English speakers, and individuals with certain types of seizures.Check my eligibility
What is being tested?
The study aims to develop new methods to measure the expectation of pain and attention related to threats using skin conductance as a metric for anxiety. These methods could help diagnose and manage PTSD and anxiety disorders by understanding how environments associated with injury influence fear of pain.See study design
What are the potential side effects?
Since this trial involves measurement techniques rather than medication or invasive treatments, traditional side effects are not applicable. However, participants may experience discomfort or stress related to the anticipation of pain during testing.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18 and 80 years old.
Select...
I understand and can follow the study's procedures.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ the whole duration of the study up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~the whole duration of the study up to 5 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Anxiety as assessed by the Spielberg Anxiety Inventory
Conditioned fear as assessed by skin conductance
Experimental Pain as assessed by a pain rating scale
Secondary outcome measures
Parts of the brain outside the predicted models.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Eye position and tense arousal over time a metrics for sustained attention in conditioned fear.Experimental Treatment1 Intervention
After conditioning the conditioned stimulus induces autonomic metrics like skin conductance and cognitive ratings like expectancy of the unconditioned stimulus after conditioning. Activity across blocks in the conditioning stage demonstrates that the skin conductance can produce a progressive decrease in skin conductance over the conditioning stage of our fear conditioning protocol. The decline is not apparently related to habituation or changes in the skin conducting electrodes or recording system. It does correspond to the decrease in performance of a visual fixation task which is part of the fear conditioning during the conditioning stage; and to an increase in the unpleasant psychologic activation termed tense arousal over the same stage. If both these changes are found he then we may conclude that sustained task related attention is produced during fear conditioning
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Who is running the clinical trial?
University of MarylandOTHER
160 Previous Clinical Trials
302,133 Total Patients Enrolled
Johns Hopkins UniversityLead Sponsor
2,262 Previous Clinical Trials
14,823,014 Total Patients Enrolled
Ohio State UniversityOTHER
829 Previous Clinical Trials
505,485 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I am between 18 and 80 years old.I experience seizures that affect my whole body or are triggered by things like lights or sounds.I have a stable and well-managed neurological condition, excluding epilepsy.I am not pregnant and use contraception if I can become pregnant.I do not have any untreated or unstable health or mental conditions.My MRI shows changes not due to normal variants or Medial Temporal Sclerosis.I understand and can follow the study's procedures.
Research Study Groups:
This trial has the following groups:- Group 1: Eye position and tense arousal over time a metrics for sustained attention in conditioned fear.
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are older adults eligible to partake in this experiment?
"This trial will accept patients between 16 and 88 years of age. There are additional research studies for those below 18 or above 65."
Answered by AI
Under what criteria are participants eligible to engage in this trial?
"This study is currently enrolling 150 volunteers between 16 and 88 years old who are suffering from fear of pain. In order to join the trial, these criteria must be met."
Answered by AI
Is recruitment open for participation in this clinical investigation?
"The clinical trial is currently in search of volunteers, with the initial posting occuring on February 8th 2012 and the last update being made on May 1st 2023."
Answered by AI
What is the total enrollment of participants for this experiment?
"Affirmative. The clinical trial is presently seeking out participants, with the original post date being February 8th 2012 and the most recent update occurring on May 1st 2023. One locale requires 150 patients for this study."
Answered by AI
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