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Behavioural Intervention

Deprescribing intervention for Frail Elderly (DROP Trial)

N/A

Waitlist Available

Led By Amanda S Mixon, MD MSPH MS

Research Sponsored by VA Office of Research and Development

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up post-snf discharge 90 days

Awards & highlights

DROP Trial Summary

This trial will evaluate the effect of reducing medications for older veterans as they transition from the hospital to a nursing home. The goal is to see if this improves outcomes like geriatric syndromes, and to understand what factors help or hinder the success of the intervention.

Eligible Conditions

Frail Elderly
Patient-Centered Care
Skilled Nursing Facilities
Geriatric Assessment

DROP Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 90-day follow-up

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~90-day follow-up

This trial's timeline: 3 weeks for screening, Varies for treatment, and 90-day follow-up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Pharmaceutical Preparations

Secondary outcome measures

Adverse Drug Withdrawal Events (composite)

Cognitive impairment (BIMS)

Delirium

+11 more

DROP Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Intervention--deprescribing protocolExperimental Treatment1 Intervention

In addition to a medication history, a study Pharmacist or Nurse Practitioner will review the reconciled total enrollment medication list. The following information will be ascertained for each medication: (1) Medication Indication; and, (2) Deprescribing rationale: Rationales for deprescribing (i.e., stopping or reducing dose) will be assessed for each medication. Deprescribing Recommendations: For each medication recommended for deprescribing, the deprescribing action will be specified as: (1) Stop prior to hospital discharge without need for monitoring; (2) Stop prior to hospital discharge with symptoms/physiologic monitoring; (3) Stop at specified time point following hospital discharge; (4) Reduce over time with monitoring until medication is stopped; (5) Reduce to lower dose without need for monitoring; (6) Reduce to lower dose with symptoms/physiologic monitoring.

Group II: Control--usual careActive Control1 Intervention

Medication History: All participants / surrogates will receive a structured interview and chart review by the study Pharmacist or Nurse Practitioner at enrollment to determine: Medications: Medications will include ANY medication with the potential for continuation at the time of hospital discharge to include pre-hospital medications, [OTC medications] and active in-hospital medications. Pre-hospital [and OTC] medications will be confirmed by Veteran/surrogate interview and pharmacy refills. If a Veteran is admitted from SNF (short-term stay), the investigators will request a copy of the Medication Administration Record (MAR) for the past 30 days. Current medications will be defined as those taken within 30 days prior to the index (enrollment) hospitalization event.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor

1,609 Previous Clinical Trials

3,306,173 Total Patients Enrolled

3 Trials studying Frail Elderly

370 Patients Enrolled for Frail Elderly

Amanda S Mixon, MD MSPH MSPrincipal InvestigatorTennessee Valley Healthcare System Nashville Campus, Nashville, TN

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the upper limit of participants that are enrolled in this experiment?

"Affirmative. Clinicaltrials.gov confirms that this research trial, originally published on October 7th 2019 is actively no searching for 215 participants across 1 site location. The study was updated as recently as July 26th 2022."

Answered by AI

Are there remaining vacancies in this research endeavor?

"Affirmative. According to clinicaltrials.gov, this scientific experiment is actively recruiting test subjects since its initial posting on October 7th 2019. This research requires 215 volunteers at 1 trial location and was last modified July 26th 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Drug Reduction in Older Patients: The DROP Trial

2019. "Drug Reduction in Older Patients: The DROP Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03722017.