High Strength, Low Strength for Vaping

Yale University School of Medicine, New Haven, CT
VapingHigh strength nicotine e-liquid - Drug
21 - 55
All Sexes

Study Summary

This trial will test if e-cigarettes provide efficient nicotine delivery to the brain and arterial blood in smokers and e-cigarette users, and if the liquid characteristics of e-cigarettes modulate this effect.

Treatment Effectiveness

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: 210 minutes

210 minutes
Brain beta-2 nicotinic acetylcholine receptor occupancy
90 minutes
Maximum arterial blood nicotine

Trial Safety

Awards & Highlights

Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

2 Treatment Groups

High Strength, Low Strength
1 of 2
Low Strength, High Strength
1 of 2

Experimental Treatment

2 Treatment Groups

Primary Treatment: High Strength, Low Strength · No Placebo Group · N/A

High Strength, Low StrengthExperimental Group · 2 Interventions: High strength nicotine e-liquid, Low strength nicotine e-liquid · Intervention Types: Drug, Drug
Low Strength, High StrengthExperimental Group · 2 Interventions: High strength nicotine e-liquid, Low strength nicotine e-liquid · Intervention Types: Drug, Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 210 minutes

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,728 Previous Clinical Trials
20,525,576 Total Patients Enrolled
2 Trials studying Vaping
317 Patients Enrolled for Vaping
National Institute on Drug Abuse (NIDA)NIH
2,305 Previous Clinical Trials
2,023,081 Total Patients Enrolled
7 Trials studying Vaping
4,839 Patients Enrolled for Vaping

Eligibility Criteria

Age 21 - 55 · All Participants · 8 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:

Frequently Asked Questions

What are the criteria for inclusion in this clinical investigation?

"To be considered for this study, participants must have prior experience with e-cigarettes and fall within the age demographic of 21 to 55. The total number of enrollees is 20." - Anonymous Online Contributor

Unverified Answer

How many participants are participating in this medical research?

"Affirmative, the clinicaltrials.gov website lists this trial as actively recruiting participants. First posted on December 30th 2022 and updated February 8th 2022, 20 volunteers are needed from a single location for this experiment." - Anonymous Online Contributor

Unverified Answer

Could individuals below the age of thirty partake in this trial?

"This clinical trial is available to individuals aged between 21 and 55. If one falls outside of this age bracket, there are 5 studies for those under 18 years old and 59 studies targeting seniors over 65." - Anonymous Online Contributor

Unverified Answer

Has any research been conducted in regards to the efficacy of various potency levels?

"Currently, 71 investigations into the efficacy of High Strength and Low Strength are being conducted worldwide. 5 trials have reached their third phase, with most taking place in Green Bay, Wisconsin. In total, 204 medical facilities are involved in this research study." - Anonymous Online Contributor

Unverified Answer

Is enrollment in this experiment open to participants at the moment?

"According to the information on clinicaltrials.gov, this study is actively seeking participants. It was initially posted in late December 2022 and has been updated recently on February 8th 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.