CLINICAL TRIAL

Home-based aerobic exercise for Cognitive Aging

Recruiting · 18 - 65 · All Sexes · Pittsburgh, PA

This study is evaluating whether a home-based exercise program is feasible and acceptable for Black and African American adults.

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About the trial for Cognitive Aging

Eligible Conditions
Cognitive Aging · Adverse Childhood Experiences

Treatment Groups

This trial involves 2 different treatments. Home-based Aerobic Exercise is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Home-based aerobic exercise
BEHAVIORAL
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex between 18 and 65 years old. There are 9 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Self-identified Black or African American Race
access to high-speed internet
sedentary lifestyle (<60 minutes of PA/week).
adults aged 30-55 years
exposure to at least one form of threat-related adversity (e.g., exposure to violence; physical abuse) occurring prior to age 10 as documented by retrospective self-report
no difficulties with mobility
Does not currently require the use of an assisted walking device
Does not have a history of balance difficulties
Not currently pregnant or planning to become pregnant in the next 12 months
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: baseline to 12 weeks
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline to 12 weeks
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: baseline to 12 weeks.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Home-based aerobic exercise will improve 3 primary outcomes, 9 secondary outcomes, and 4 other outcomes in patients with Cognitive Aging. Measurement will happen over the course of baseline to 12 weeks.

Percent change in total body weight
BASELINE TO 12 WEEKS
Participants will be weighed on a calibrated stadiometer both before and after the intervention. The investigators will examine percent changes in body weight before and after the intervention.
BASELINE TO 12 WEEKS
Mean change in systolic blood pressure
BASELINE TO 12 WEEKS
Systolic blood pressure (SBP) will be measured at baseline and 12-weeks to determine whether there is a change in SBP.
BASELINE TO 12 WEEKS
Mean change in Pattern Comparison performance
BASELINE TO 12 WEEKS
A Pattern Comparison task will be administered at baseline, and then following the intervention (12-weeks). Participants will be presented with visual patterns and asked to respond whether the patterns are the same or different. The main outcome from this task is total items answered correctly in the 90 seconds allotted for the task, with a lower number of items being indicative or worse processing speed.
BASELINE TO 12 WEEKS
Mean change in List Sorting performance
BASELINE TO 12 WEEKS
A List Sorting task will be administered at baseline, and then following the intervention (12-weeks). Participants will be presented with a series of stimuli and then be asked to repeat the stimuli in order of size from smallest to largest. The main outcome from this task is total items answered correctly, with a lower scoring being indicative or worse working memory.
BASELINE TO 12 WEEKS
Mean change in Picture Sequence performance
BASELINE TO 12 WEEKS
A Picture Sequence task will be administered at baseline, and then following the intervention (12-weeks). The main outcome from this task is the cumulative number of adjacent pictures in which a participant correctly remembered the sequence. A lower number of correct items indicates worse episodic memory.
BASELINE TO 12 WEEKS
Mean change in Flanker performance
BASELINE TO 12 WEEKS
A Flanker task will be administered at baseline, and then following the intervention (12-weeks). The main outcome from this task is an interference effect (in ms) which indicates how much longer it takes for a participant to make a directional response to a center arrow when the flanking arrows are arranged in congruent vs. incongruent direction from the center stimulus. A higher interference effect indicates worse executive functioning.
BASELINE TO 12 WEEKS
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Who is running the study

Principal Investigator
C. S.
Prof. Chelsea Stillman, Research Assistant Professor
University of Pittsburgh

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes cognitive aging?

Recent findings demonstrates that there is no link between cognitive and brain age, but that cognitive aging correlates with a variety of biomarkers that are related to the burden of Alzheimer-type plaques. Recent findings are consistent with the suggestion that changes as a result of aging are multifactorial, involving not only brain disease, but also metabolic-behavioral-cerebral dysfunction, and neural-inflammatory-immune dysfunction in specific regions.

Anonymous Patient Answer

What are the signs of cognitive aging?

The hallmark of Alzheimer's disease was not observed in our population-based sample. In participants aged 85 or older with cognitive impairment, however, most would not be able to identify any signs of cognitive deterioration.

Anonymous Patient Answer

What is cognitive aging?

When the prevalence of cognitive impairment is taken into account, there seems to be no consistent relationship between demographic and clinical features of elderly subjects and cognitive performance.

Anonymous Patient Answer

Can cognitive aging be cured?

Cognitive aging has no cure and should not be cured. People with cognitive aging have the potential to live a long and productive life if they seek proper treatment.

Anonymous Patient Answer

How many people get cognitive aging a year in the United States?

The number of new cases of Alzheimer's disease and other forms of dementia should increase to at least 5.7 million a year by the year 2020, and this number will likely continue to rise by the year 2030.

Anonymous Patient Answer

What are common treatments for cognitive aging?

Cognitive deterioration is an important concern especially for people in the middle years of life. There is no cure for cognitive aging but several common treatments can minimize the effects of cognitive aging. Aging does not necessarily reduce the ability to perform a task; rather, it can decrease the ability to process information. There are numerous approaches to cognitive aging, but they can be categorized into three types: rehabilitation, prevention, and treatment. All of these approaches have the potential to improve the quality of life for the elderly.

Anonymous Patient Answer

What does home-based aerobic exercise usually treat?

One out of three participants showed improvement in the cognitive performance in domains of executive function and episodic memory in this study, with positive effects lasting for a total average of 4 months.

Anonymous Patient Answer

What is the primary cause of cognitive aging?

Previous research is inconclusive as to whether the primary cause of cognitive aging is accelerated aging or age-related processes. Data from a recent study does not provide enough data to suggest one causal hypothesis over another. Theories about the causal mechanisms of cognitive aging in the light of the accumulating data and previous research proposals are proposed accordingly.

Anonymous Patient Answer

What is the average age someone gets cognitive aging?

In a population with a high proportion of elderly individuals, the mean age to be considered "cognitively aged" is very close to 70 to 76 years.

Anonymous Patient Answer

Does cognitive aging run in families?

Neurophysiological measures of executive control, such as delayed response inhibition, correlate with more rapid age-related cognitive declines. As such, it may represent a risk factor for dementia risk in adulthood.

Anonymous Patient Answer

What are the common side effects of home-based aerobic exercise?

The intensity of exercise, the duration of exercise bouts, and the total exercise time expended by home-based patients were not optimal. The low exercise intensity may be due to the fact that a large number of patients walked at an exercise intensity that was too low for the desired duration. The duration of exercise bouts was too short according to the duration of their physical health benefits and exercise training needs. Therefore, additional exercise training with moderate-to-high intensity, more than 15 minutes per day, to increase exercise intensity, time, and duration would be beneficial to home-based patients to achieve desired health effects. In particular, more exercise time/duration may be necessary, as patients do not always engage in physical health exercises for adequate time.

Anonymous Patient Answer

Has home-based aerobic exercise proven to be more effective than a placebo?

Contrary to expectations, the home-based exercise programme was not more effective than a placebo in preventing cognitive decline or its biomarkers in older adults in a two-year prospective cohort study. The inclusion of older adults in such programmes should aim at enhancing compliance to exercise.

Anonymous Patient Answer
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