Types of Exercise for Exercise

1
Effectiveness
1
Safety
East Carolina University, Greenville, NC
Types of Exercise - Behavioral
Eligibility
18 - 65
Female
Eligible conditions
Exercise

Study Summary

This study is evaluating whether exercise during pregnancy may help reduce the risk of heart disease in offspring.

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Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Types of Exercise will improve 1 primary outcome and 4 secondary outcomes in patients with Exercise. Measurement will happen over the course of At Birth.

Week 36
Global and targeted metabolomics analysis will be conducted to map out pathways and mechanisms from regular maternal exercise. Docosahexaenoic acid (DHA), Eicosapentaenoic Acid (EPA), Docosapentaenoic Acid (DPA), and Arachidonic acid (ARA).
At Birth
Human Skeletal Muscles cells grown from MSCs will have insulin responsiveness measured
Month 1
A trained (blinded) researcher will measure bicep, tricep, and subscapular skinfold measures, circumferences (abdominal, head, mid-upper arm), and lengths (body, femur, leg, humeral). All measures are recorded as mm.
A trained (blinded) researcher will measure body weight on an infant scale
Peabody Developmental Motor Scales, 2nd edition (PDMS-2) will be performed by a pediatric physical therapist (blinded to group classification) to measure gross motor skills of infants up to 12 months of age.

Trial Safety

Safety Estimate

1 of 3

Trial Design

3 Treatment Groups

No Control Group
Aerobic Type of Exercise

This trial requires 160 total participants across 3 different treatment groups

This trial involves 3 different treatments. Types Of Exercise is the primary treatment being studied. Participants will be divided into 3 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Aerobic Type of Exercise
Behavioral
This group will participate in aerobic exercise intervention 3 times per week from enrollment to delivery. The aerobic training (AT) group will perform a continuous aerobic exercise of their choosing (e.g., treadmill, ellipticals, stairs, Zumba, or outside walking/jogging). Participants' ability to choose an aerobic activity that they are comfortable with and enjoy is intended to improve compliance.
Resistance Type of Exercise
Behavioral
This group will participate in resistance exercise intervention 3 times per week from enrollment to delivery.The resistance training (RT) group will perform three sets of 12-15 repetitions of 10-12 resistance exercises in a circuit, with rest of 30-60 seconds between sets as needed. Participants will use a combination of Cybex machines (Cybex International, Medway, MA), resistance bands, and free weights. Routines will change every 3 weeks to add variety and improve compliance.
Combination Type of Exercise
Behavioral
This group will participate in combination (aerobic+resistance) exercise intervention 3 times per week from enrollment to delivery. The combination (CT) group will alternate between resistance and aerobic exercises. Participants will perform 4.5 minute bouts of aerobic exercise and perform four resistance exercises of 12-15 repetition that vary between aerobic bouts[17-19]. The aerobic exercise bouts will be performed on the aerobic machine of the participant's choosing as described above. The resistance routine will follow similar guidelines as the resistance group.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: at 1 month postnatal visit
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly at 1 month postnatal visit for reporting.

Who is running the study

Principal Investigator
L. M.
Prof. Linda May, Associate Professor
East Carolina University

Closest Location

East Carolina University - Greenville, NC

Eligibility Criteria

This trial is for female patients between 18 and 65 years old. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
<16 weeks gestation
You can contact us by phone or email if you are pregnant and have a singleton pregnancy. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How serious can exercise be?

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It appears that low-impact regular sporting activity offers some relief from symptoms in some patients with PANDAS. However, there is no conclusive evidence regarding efficacy or safety of regular high-impact sporting activity.

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Can exercise be cured?

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It is impossible to cure exercise. It is possible to make exercise safe, to keep healthy physical activity a priority, and the physical activity of millions of people can produce positive results.

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What is exercise?

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Regular, moderate to brisk (7-12 MET h/wk) and prolonged aerobic (aerobic, >12 MET h/wk) exercise improves cardiovascular fitness, muscle strength and gait steadiness relative to non-exercising controls. The effect is likely mediated by changes in the brain reward pathways.

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How many people get exercise a year in the United States?

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Between 16 and 45 million American adults are estimated to participate in some form of regular physical activity. However, only around 12% of those who participate in such exercise achieve the recommended levels in the US. The findings from this study highlight the need to develop and implement programs aimed at increasing physical activity and providing the means to support habitual physical activity at a population level.

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What causes exercise?

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A combination of genes, environmental factors, and health habits of an individual is probably required to trigger an aerobic response. People with a genetic predisposition, though, are usually more physically active. Individuals who engage in aerobic exercise often have an improved quality of life.

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What are common treatments for exercise?

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There is no one single therapy that can help everyone, so we have to focus on the treatment options that best address our individual requirements. Exercise has a positive effect on a lot of people with different disorders and problems.

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What are the signs of exercise?

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Exercise and physical activity can be used as part of a lifestyle program targeted at maintaining health and preventing illnesses, but must be balanced with activities where health is not a consideration.

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Is types of exercise safe for people?

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Overall exercise is safe in people with cancer. Specific exercise-related risks are lower among people with cancer. These data suggest that people with cancer can follow the same exercise recommendations that are recommended for the general public.

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Have there been any new discoveries for treating exercise?

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Recently there seems to be a trend in the medical field for exercising to cure exercise. There are no conclusive scientific studies to verify the effectiveness of exercise in managing disease. There are many risks of exercise that we have not fully addressed. Further research is needed on how to maximize the benefits of exercise for disease.

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Who should consider clinical trials for exercise?

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There seems to be a need for clinical trials targeted specifically to older adults. There are limitations to our results: we know nothing about whether people's expectations were met. To be useful, any trial would likely need to include a comparator group whose expectations are the same but which is not as functionally impaired as the patients.

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What is the average age someone gets exercise?

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The average age of someone getting the recommended amount of exercise is in their 30s. This is about the same age that most patients are diagnosed with rheumatoid arthritis and CFS. People with this disease and others who want to get exercise at a young age could be encouraged to join local communities that support exercise and help the community get more exercise. If a youth was really willing to get a little exercise they could be instructed how to exercise at a younger age, and if that was also possible from a health professional like a physician that could be done as well.

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What is the latest research for exercise?

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The findings of the studies were mixed with most of them being from well-controlled randomized studies with homogeneous and homogenous populations and the studies were from the last 12 months or so. Thus we were unable to conclude a strong relationship between exercise and reduced risk of PCa development. There is an emerging interest in more randomised trials of exercise in young men, especially for developing countries.

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