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Types of Exercise for Exercise

N/A

Waitlist Available

Research Sponsored by East Carolina University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at 1 month postnatal visit

Awards & highlights

Study Summary

This trial will assess the effects of maternal exercise on offspring health outcomes, testing the hypothesis that exercise during pregnancy alters skeletal muscle in a manner which decreases the risk of heart disease in offspring.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at 1 month postnatal visit

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at 1 month postnatal visit

This trial's timeline: 3 weeks for screening, Varies for treatment, and at 1 month postnatal visit for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Human Skeletal Muscles cells grown from MSCs will have insulin responsiveness measured

Secondary outcome measures

A trained (blinded) researcher will measure bicep, tricep, and subscapular skinfold measures, circumferences (abdominal, head, mid-upper arm), and lengths (body, femur, leg, humeral). All measures are recorded as mm.

A trained (blinded) researcher will measure body weight on an infant scale

Global and targeted metabolomics analysis will be conducted to map out pathways and mechanisms from regular maternal exercise. Docosahexaenoic acid (DHA), Eicosapentaenoic Acid (EPA), Docosapentaenoic Acid (DPA), and Arachidonic acid (ARA).

+1 more

Trial Design

4Treatment groups

Experimental Treatment

Active Control

Group I: Resistance Type of ExerciseExperimental Treatment1 Intervention

This group will participate in resistance exercise intervention 3 times per week from enrollment to delivery.The resistance training (RT) group will perform three sets of 12-15 repetitions of 10-12 resistance exercises in a circuit, with rest of 30-60 seconds between sets as needed. Participants will use a combination of Cybex machines (Cybex International, Medway, MA), resistance bands, and free weights. Routines will change every 3 weeks to add variety and improve compliance.

Group II: Combination Type of ExerciseExperimental Treatment1 Intervention

This group will participate in combination (aerobic+resistance) exercise intervention 3 times per week from enrollment to delivery. The combination (CT) group will alternate between resistance and aerobic exercises. Participants will perform 4.5 minute bouts of aerobic exercise and perform four resistance exercises of 12-15 repetition that vary between aerobic bouts[17-19]. The aerobic exercise bouts will be performed on the aerobic machine of the participant's choosing as described above. The resistance routine will follow similar guidelines as the resistance group.

Group III: Aerobic Type of ExerciseExperimental Treatment1 Intervention

This group will participate in aerobic exercise intervention 3 times per week from enrollment to delivery. The aerobic training (AT) group will perform a continuous aerobic exercise of their choosing (e.g., treadmill, ellipticals, stairs, Zumba, or outside walking/jogging). Participants' ability to choose an aerobic activity that they are comfortable with and enjoy is intended to improve compliance.

Group IV: Non-Exercise ControlActive Control1 Intervention

This group will come in regularly for measurements, but will not have an exercise intervention. If necessary for retention of participants, then we will meet with controls 3 times a week to stress reduction techniques.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Types of Exercise

2018

N/A

~170

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Who is running the clinical trial?

East Carolina UniversityLead Sponsor

107 Previous Clinical Trials

38,642 Total Patients Enrolled

American Heart AssociationOTHER

324 Previous Clinical Trials

4,933,611 Total Patients Enrolled

1 Trials studying Exercise

200 Patients Enrolled for Exercise

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Am I eligible to volunteer for this clinical study?

"Applicants hoping to join this medical study must be physically active and between 18-35 years old. Ultimately, the clinical trial seeks to enrol a total of 160 participants."

Answered by AI

Is the recruitment process for this experiment still active?

"As listed on clinicaltrials.gov, this medical research is no longer recruiting participants; the trial was initially made public in September of 2018 and last updated on February 18th 2022. In contrast, there are currently 95 other studies that are actively enrolling patients."

Answered by AI

Are elderly participants being accepted into this clinical experiment?

"This clinical study is looking for patients aged 18 to 35. However, there are auxiliary trials available if you are younger than 18 or older than 65, with 12 and 58 studies respectively devoted to those age groups."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Influence of Maternal Exercise on Infant Skeletal Muscle and Metabolomics

Linda May 2018. "Influence of Maternal Exercise on Infant Skeletal Muscle and Metabolomics". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03838146.