CLINICAL TRIAL

Contingency Management for Cocaine Use Disorders

Recruiting · 18+ · All Sexes · Lexington, KY

This study is evaluating whether reduced cocaine use is associated with positive impacts for individuals with cocaine use disorder.

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About the trial for Cocaine Use Disorders

Treatment Groups

This trial involves 2 different treatments. Contingency Management is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Contingency Management
BEHAVIORAL
Experimental Group 2
Contingency Management
BEHAVIORAL

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Contingency Management
2003
Completed Phase 2
~3230

Eligibility

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Someone who meets the moderate-severe Cocaine Use Disorder Criteria is addicted to cocaine and experiences withdrawal symptoms and negative consequences as a result of their addiction. show original
Many people who use cocaine do not seek treatment for their addiction. show original
The person is able to commit to doing an intervention for 12 weeks, and then staying involved for another 24 weeks. show original
Age 18 or older
is an important criterion for selecting patients for treatment of cocaine dependence show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: At baseline, 6 and 12 weeks after study entry, 4, 12 and 24 weeks after study completion.
Screening: ~3 weeks
Treatment: Varies
Reporting: At baseline, 6 and 12 weeks after study entry, 4, 12 and 24 weeks after study completion.
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: At baseline, 6 and 12 weeks after study entry, 4, 12 and 24 weeks after study completion..
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Trial Expert
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- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Contingency Management will improve 7 primary outcomes and 10 secondary outcomes in patients with Cocaine Use Disorders. Measurement will happen over the course of At baseline, week 12 of study participation, 4, 12 and 24 weeks after study completion.

Cocaine use disorder
AT BASELINE, WEEK 12 OF STUDY PARTICIPATION, 4, 12 AND 24 WEEKS AFTER STUDY COMPLETION
Cocaine use disorder severity will be assessed with the structured clinical interview for DSM-5 throughout study participation. Results will be coded as none, mild, moderate or sever.
AT BASELINE, WEEK 12 OF STUDY PARTICIPATION, 4, 12 AND 24 WEEKS AFTER STUDY COMPLETION
HIV Risk Behavior
AT BASELINE, 1 TIME WEEKLY DURING THE 12 WEEK INTERVENTION, 4, 8, 12 AND 24 WEEKS AFTER STUDY COMPLETION
HIV Risk Behavior will be assessed with the HIV Risk Behavior Scale throughout subject participation.
AT BASELINE, 1 TIME WEEKLY DURING THE 12 WEEK INTERVENTION, 4, 8, 12 AND 24 WEEKS AFTER STUDY COMPLETION
Depression
AT BASELINE, 1 TIME WEEKLY DURING THE 12 WEEK INTERVENTION, 4, 8, 12 AND 24 WEEKS AFTER STUDY COMPLETION
Depressive symptoms will be assessed with the Hamilton Depression Scale throughout subject participation.
AT BASELINE, 1 TIME WEEKLY DURING THE 12 WEEK INTERVENTION, 4, 8, 12 AND 24 WEEKS AFTER STUDY COMPLETION
Sleep
AT BASELINE, 1 TIME WEEKLY DURING THE 12 WEEK INTERVENTION, 4, 8, 12 AND 24 WEEKS AFTER STUDY COMPLETION
Sleep will be assessed with the Saint Mary's Hospital Sleep questionnaire throughout subject participation.
AT BASELINE, 1 TIME WEEKLY DURING THE 12 WEEK INTERVENTION, 4, 8, 12 AND 24 WEEKS AFTER STUDY COMPLETION
Weight
AT BASELINE, 3 DAYS/WEEK DURING THE 12 WEEK INTERVENTION, 4, 8, 12 AND 24 WEEKS AFTER STUDY COMPLETION
Weight will be recorded in kilograms throughout subject participation.
AT BASELINE, 3 DAYS/WEEK DURING THE 12 WEEK INTERVENTION, 4, 8, 12 AND 24 WEEKS AFTER STUDY COMPLETION
Cocaine use
24 WEEKS AFTER STUDY COMPLETION
Cocaine use will be assessed with qualitative urine screens during subject visits. Results will be coded as positive or negative.
24 WEEKS AFTER STUDY COMPLETION
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Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the latest developments in contingency management for therapeutic use?

Although the studies that have been conducted so far in therapeutic CM (i.e., studies that employ CM in a clinical setting to prevent relapse of drug-use problems) represent a small percentage of published studies, the results are promising and emphasize that additional research is needed. Implications for future directions of CM research are outlined.

Anonymous Patient Answer

What are common treatments for cocaine use disorders?

These data suggest that a variety of approaches may prove to be effective, including (a) a combination of behavioral, social, and pharmacological interventions; (b) short-term medical detoxification in conjunction with behavioral treatment; and (c) 12-step based (CUD) self-help groups that focus on relapse prevention. Effective recovery methods need to be developed in order to maximize the outcomes for people with CUDs.

Anonymous Patient Answer

How many people get cocaine use disorders a year in the United States?

About 25,000 Americans experience cocaine use during a year. Cocaine use disorders were more common in blacks than in whites and among people from low socioeconomic backgrounds and adolescents.

Anonymous Patient Answer

Can cocaine use disorders be cured?

Treatment for cocaine-dependent individuals with a short-term inpatient treatment programme is associated with significant positive outcomes at 3 yr follow-up, with no clinically significant treatment effects on major substance use or health-related problems, as defined by a range of objective measures in clinical and experimental studies.

Anonymous Patient Answer

What is cocaine use disorders?

Cocaine UDs are highly prevalent in the United States and Canada, with cocaine use prevalence higher in men than in women and among minorities. The U.S. and Canadian cocaine UDs prevalence rates are higher than national studies in other countries, and higher than cocaine use rates reported at the state and city level.

Anonymous Patient Answer

What causes cocaine use disorders?

Drugs that cause physical dependence or sensitization to cocaine or that prevent its detoxication also lead to cocaine addiction. However, this depends on both the drug used as well as its rate of elimination. The same thing applies to the effectiveness of drugs used to prevent cocaine use in the future. It is still unclear why some individuals get physically dependent or why not, but this depends on their hereditary and environmental factors as well as their current drug use.

Anonymous Patient Answer

What are the signs of cocaine use disorders?

Cocaine-dependent patients use cocaine more in the presence of interpersonal cues, and the intensity of craving increases with the degree of craving experienced by the subjects. The amount of cocaine use also increases when cocaine use occurs in the presence of interpersonal cues. Cues do not affect the onset or intensity of cocaine use in the absence of interpersonal cues. The presence of interpersonal cues and the level of cocaine use can determine the degree in which a cue will induce relapse.

Anonymous Patient Answer

What is the average age someone gets cocaine use disorders?

There is a bimodal prevalence pattern of cocaine dependence in a large sample of adolescents, with an earlier start in the younger (12 or 13 years) and older (15 or 16 years) group. This pattern of cocaine use disorders among adolescence is consistent with the hypothesis that there may be a biologically distinct sub-populations of adolescent cocaine users that experience early onset of use, late onset of use, or do not show any progression to dependence during adolescence.

Anonymous Patient Answer

How does contingency management work?

Both self-monitoring and behavioral goals improve abstinence for the entire 12-week sample. All patients who received contingency management therapy, regardless of type of goal, did significantly better than those who received only care planning and counseling.

Anonymous Patient Answer

How serious can cocaine use disorders be?

Serious complications may occur from cocaine use disorders. A high frequency of comorbidity, socioeconomic status, and medical management all affect outcome of cocaine use disorders.

Anonymous Patient Answer

What does contingency management usually treat?

Using a small amount of money for every dose of medication delivered to the body is an effective and efficient means for drug addicts to maintain drug abstinence. A recent, short-term, randomized, placebo-controlled study investigated the effectiveness of contingency management for cocaine addicts. The study design consisted of two 12-week assessments of abstinence outcomes, with follow up examinations occurring at week 48. Participants who participated in the contingency management treatment (CMT) group were encouraged to enter a 1-hour counseling session every 3 weeks in which they received their money. CMT participants also received a 1-hour, motivational, counseling session 3 times a week for 2 weeks before the beginning of the experiment.

Anonymous Patient Answer

Does contingency management improve quality of life for those with cocaine use disorders?

Recent findings found a relationship between CM and improved QOL in those with cocaine use disorders and provides support for the use of CM with those who use cocaine to help improve their mental health.

Anonymous Patient Answer
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