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Broccoli seed extract with mustard seed powder for Sulforaphane Bioavailability

N/A

Waitlist Available

Research Sponsored by Appalachian State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from pre-ingestion to 8- and 24-hours post-ingestion

Awards & highlights

Study Summary

This study is evaluating whether a supplement containing broccoli can improve health in people with dementia.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from pre-ingestion to 8- and 24-hours post-ingestion

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from pre-ingestion to 8- and 24-hours post-ingestion

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from pre-ingestion to 8- and 24-hours post-ingestion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Urine concentration of sulforaphane

Secondary outcome measures

Urine concentration of dithiocarbamate

Side effects data

From 2016 Phase 3 trial • 854 Patients • NCT00003389

98%

Anemia

93%

Leukocytes decreased

90%

Lymphopenia

84%

Neutrophils decreased

78%

Neuropathy-sensory

75%

Alopecia

74%

Fatigue

67%

Nausea

60%

Hyperglycemia

52%

Constipation

46%

Hypoalbuminemia

40%

Myalgia

34%

Stomatitis

33%

Insomnia

32%

Vomiting

27%

Platelets decreased

26%

Alkaline phosphatase increased

26%

Aspartate aminotransferase increased

23%

Dyspnea

20%

Dyspepsia

19%

Dysphagia

19%

Headache

16%

Anorexia

16%

Arthralgia

15%

Neuropathy-motor

15%

Abdominal pain

14%

Infection w/o neutropenia

14%

Cough

14%

Fever

13%

Rash/desquamation

13%

Diarrhea w/o prior colostomy

12%

Bone pain

11%

Weight gain

11%

Taste disturbance

11%

Anxiety/agitation

10%

Sweating

10%

Radiation dermatitis

Rigors/chills

Dizziness/lightheadedness

Injection site reaction

Hypoglycemia

Dysphagia-esophageal radiation

Blood bilirubin increased

Chest pain

Pain-other

Phlebitis

Creatinine increased

Edema

Pruritus

Hot flashes

Infection w/ grade 3 or 4 neutropenia

Weight loss

Muscle weakness

Depression

Mouth dryness

Transfusion: pRBCs

Pneumonitis/pulmonary infiltrates

Thrombosis/embolism

Febrile neutropenia

Irregular menses

Nail changes

Allergic rhinitis

Allergic reaction

Infection w/ unknown ANC

Syncope

Sinus tachycardia

Dehydration

Neuropathic pain

100%

80%

60%

40%

20%

Study treatment Arm

Arm B (Stanford V)

Arm A (ABVD)

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Broccoli seed extract with mustard seed powderExperimental Treatment1 Intervention

A single dose dietary supplement made up of a mixture of 385 mg broccoli seed extract delivering 50 mg GR (115 umol GR), 145 mg mustard seed powder containing enough active myrosinase (enzyme) to fully hydrolyze the GR in the capsule to SF post-ingestion (~30 units myrosinase activity) and 100 mg vitamin C (as ascorbic acid).

Group II: Broccoli seed extractActive Control1 Intervention

A single dose dietary supplement made up of 385 mg broccoli seed extract delivering 50 mg GR (115 umol GR) and 100 mg vitamin C (as ascorbic acid).

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Broccoli seed extract with mustard seed powder

2022

N/A

~20

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Who is running the clinical trial?

Appalachian State UniversityLead Sponsor

40 Previous Clinical Trials

2,181 Total Patients Enrolled

Brassica Foundation for Chemoprotection ResearchUNKNOWN

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Recent research and studies

clinicaltrials.govStudy

Broccoli Sulforaphane Bioavailability With Mustard

2022. "Broccoli Sulforaphane Bioavailability With Mustard". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04946526.

~6 spots leftby Apr 2025

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