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Analgesic

IV vs Oral Acetaminophen for Surgical Pain

N/A

Waitlist Available

Research Sponsored by Thomas Jefferson University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Single level lumbar micro disk surgery

Ages 18-65

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day of surgery

Awards & highlights

Study Summary

This trial investigates if there is a difference in pain relief between intravenous and oral acetaminophen given before surgery. The hypothesis is that the intravenous form does not provide better pain relief or decrease opioid use compared to the oral form.

Who is the study for?

This trial is for individuals aged 18-65 who are undergoing a single-level lumbar microdiscectomy, which is a type of back surgery. It's not open to those with previous back surgeries, opioid tolerance, pregnancy, or morbid obesity.Check my eligibility

What is being tested?

The study compares the effectiveness of preoperative pain management using intravenous (IV) versus oral acetaminophen in patients having lumbar discectomy. The goal is to see if IV acetaminophen offers better pain relief or reduces the need for opioids after surgery compared to its oral counterpart.See study design

What are the potential side effects?

Possible side effects from both forms of acetaminophen may include allergic reactions, skin rashes, headache, and gastrointestinal issues like nausea or constipation. Overdose can lead to liver damage.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have had a single level lumbar microdisk surgery.

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I am between 18 and 65 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day of surgery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day of surgery

This trial's timeline: 3 weeks for screening, Varies for treatment, and day of surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Postoperative pain scores

Secondary outcome measures

Quantity of intraoperative and postoperative opioids administered.

Trial Design

2Treatment groups

Active Control

Group I: intravenous acetaminophenActive Control1 Intervention

Patients in this arm of the study will receive IV acetaminophen and an oral placebo

Group II: oral acetaminophenActive Control1 Intervention

Patients in this arm of the study will receive oral acetaminophen and an IV placebo

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Thomas Jefferson UniversityLead Sponsor

444 Previous Clinical Trials

145,524 Total Patients Enrolled

6 Trials studying Pain

552 Patients Enrolled for Pain

Media Library

Acetaminophen (Analgesic) Clinical Trial Eligibility Overview. Trial Name: NCT02067442 — N/A

Pain Research Study Groups: intravenous acetaminophen, oral acetaminophen

Pain Clinical Trial 2023: Acetaminophen Highlights & Side Effects. Trial Name: NCT02067442 — N/A

Acetaminophen (Analgesic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02067442 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are people who are more than 30 years old permitted to participate in this experiment?

"The age boundaries for this clinical trial are established, with a minimum of 18 years and no more than 65."

Answered by AI

What health issues respond best to intravenous acetaminophen?

"Intravenous acetaminophen is typically prescribed to combat catarrh, as well as for relief of rhinorrhoea, musculoskeletal pain and muscle contractions."

Answered by AI

How many individuals are currently taking part in this research endeavor?

"At this juncture, there is not currently a call for participants in the clinical trial. It was first announced to the public on August 1st 2013 and had its most recent revisions on March 17th 2015. Should you be searching for an alternate medical study, 345 trials researching pain are presently enrolling patients and 90 studies involving intravenous acetaminophen have opened recruitment as well."

Answered by AI

Is it possible to participate in this research endeavor?

"This medical research is searching for 100 individuals, aged 18 to 65 years old with chronic pain. In order to be considered eligible, potential participants must meet the previously mentioned age requirement."

Answered by AI

Are there any prior trials that have assessed the effects of intravenous acetaminophen?

"Currently, there are 90 studies exploring the efficacy of intravenous acetaminophen. 27 of those research projects have advanced to their third phase; with most being based around Pittsburgh, Pennsylvania - but 1004 locations hosting trials for this medication."

Answered by AI

Is the enrollment period still open for this research project?

"This clinical trial, which was posted in August 2013 and modified in March 2015, is not currently recruiting patients. Nevertheless, there are 435 other medical studies actively searching for volunteers."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Prospective, Randomized, Double Blind Study Comparing IV vs PO Acetaminophen in Patients Undergoing Lumbar Discectomy

2013. "Prospective, Randomized, Double Blind Study Comparing IV vs PO Acetaminophen in Patients Undergoing Lumbar Discectomy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02067442.

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