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Procedure

ECMO for ARDS (ULTIMATE Trial)

N/A

Waitlist Available

Led By Niall Ferguson, MD, MSc

Research Sponsored by University of Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, an average of 2 years

Awards & highlights

ULTIMATE Trial Summary

This trial is testing whether using a specific type of ventilation (ultra-protective ventilation) with ECMO support can help improve outcomes for people with early moderate-severe ARDS, compared to using the best current conventional ventilation.

ULTIMATE Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, an average of 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, an average of 2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of patients recruited for the study

Proportion of patients adhering to the study protocol

Proportion of patients crossing over to VV ECMO

Secondary outcome measures

Health-related quality of life

Length of stay

Mortality

+3 more

ULTIMATE Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Ultra-protective ventilation with ECMOExperimental Treatment1 Intervention

Group II: Best conventional ventilationActive Control1 Intervention

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Venovenous ECMO

2023

N/A

~5060

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of TorontoLead Sponsor

689 Previous Clinical Trials

1,018,571 Total Patients Enrolled

University Health Network, TorontoOTHER

1,468 Previous Clinical Trials

484,418 Total Patients Enrolled

Niall Ferguson, MD, MScPrincipal InvestigatorUniversity Health Network, Toronto

3 Previous Clinical Trials

6,584 Total Patients Enrolled

Media Library

Ultra-Low Tidal Volume Mechanical Ventilation (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT04832789 — N/A

Acute Respiratory Distress Syndrome Research Study Groups: Ultra-protective ventilation with ECMO, Best conventional ventilation

Acute Respiratory Distress Syndrome Clinical Trial 2023: Ultra-Low Tidal Volume Mechanical Ventilation Highlights & Side Effects. Trial Name: NCT04832789 — N/A

Ultra-Low Tidal Volume Mechanical Ventilation (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04832789 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any open enrollments for this clinical trial currently being accepted?

"Per the clinicaltrials.gov platform, this investigation is not currently enrolling volunteers. The trial was inaugurated on June 1st 2021 and concluded its recruitment phase in April of that year. Despite no longer accepting participants for the current study, there are still 90 active trials recruiting patients at present."

Answered by AI

What is the aim of this research endeavor?

"The primary assesment of this two year trial is the adherence to its protocol. Secondary measures include occurrences of non-pulmonary organ dysfunction, barotrauma incidents, and changes in quality of life as quantified by EQ-5D telephone interviews."

Answered by AI

How many health care facilities are conducting this research endeavor?

"This medical trial is running at 15 sites, with New york Presbyterian Hospital in the Big Apple, University of Alberta Hospital in Edmonton and OHSU hospital in Portland being amongst them."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

Eddy Fan 2021. "Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04832789.

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