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Dietary Fat

Canola oil for Healthy Subjects (COIL Trial)

N/A
Waitlist Available
Led By Vuksan Vladimir, PhD
Research Sponsored by Unity Health Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 separate mornings, blood pressure measurements will be taken at baseline, 60, 120 and 180 minutes. blood samples will be taken at baseline 15, 30, 45, 60, 90 and 120 minutes
Awards & highlights

COIL Trial Summary

The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels. It is hypothesized that butter will have the most detrimental effect on acute vascular function. Canola, grapeseed and chia oil with their decreased content of SFA are hypothesized to impair vascular function to a lesser extent.

COIL Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 separate mornings, blood pressure measurements will be taken at baseline, 60, 120 and 180 minutes. blood samples will be taken at baseline 15, 30, 45, 60, 90 and 120 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 separate mornings, blood pressure measurements will be taken at baseline, 60, 120 and 180 minutes. blood samples will be taken at baseline 15, 30, 45, 60, 90 and 120 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
To compare 5 different dietary fat sources in a liquid meal on postprandial changes in augmentation index (AIx)
Secondary outcome measures
To investigate whether these dietary fat sources will result in blood pressure changes and a differential glycemic response

COIL Trial Design

5Treatment groups
Experimental Treatment
Placebo Group
Group I: Grapeseed oilExperimental Treatment5 Interventions
Group II: Coconut oilExperimental Treatment5 Interventions
Group III: Chia oilExperimental Treatment5 Interventions
Group IV: Canola oilExperimental Treatment5 Interventions
Group V: ButterPlacebo Group5 Interventions

Find a Location

Who is running the clinical trial?

Unity Health TorontoLead Sponsor
536 Previous Clinical Trials
447,505 Total Patients Enrolled
Vuksan Vladimir, PhDPrincipal InvestigatorRisk Factor Modification Centre - St. Michael's Hospital
William Watson (Qualified investigator), MDPrincipal InvestigatorUnity Health Toronto

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Comparison of Dietary Fats on Vascular Parameters
2014. "Comparison of Dietary Fats on Vascular Parameters". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01876394.
~2 spots leftby Apr 2025
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